Abundance of repetitive sequence elements in the mouse testis-specific lactate dehydrogenase-C gene |
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Authors: | Olsson Per G Tsujioka Hiroshi Narisawa Sonoko Goldberg Erwin Millán José Luis |
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Affiliation: | Department of Medical Biosciences, Medical Genetics, Ume? University, Ume?, Sweden. |
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Abstract: | We have cloned and sequenced the entire mouse ldhc gene and mapped it physically in relation to the somatic ldha gene. The 2 genes were found to be oriented in head-to-tail fashion with about a 6-kilobase (kb) distance between the 3' end of ldha and the 5' end of ldhc. The ldhc gene is composed of 43% repetitive elements compared to only 16% in the ldha gene. Despite the close physical distance of mouse ldha and ldhc, the 2 genes have a very different content of repetitive elements, and this most likely reflects different levels of selective pressure. |
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