人脑星形细胞瘤STAT3和Survivin的表达及其意义

目的探讨信号转导与转录激活因子3（STAT3）和生存素（Survivin）在人脑星形细胞瘤中的表达及其意义。方法采用免疫组织化学Elivision方法检测53例脑星形细胞瘤和10例正常脑组织中STAT3、P-STAT3（磷酸化STAT3）及Survivin的表达水平。结果STAT3、P-STAT3及Survivin蛋白在脑星形细胞瘤中的表达阳性率均明显高于正常脑组织（P均〈0.01）,且与星形细胞瘤病理级别有关（P均〈0.05）,与患者年龄、性别及发生部位无关（P均〉0.05）。STAT3、P-STAT3及Survivin蛋白存在正相关。结论STAT3及Survivin的高表达可能在脑星形细胞瘤的发展过程中具有重要作用。

Expression and Significance of STAT3 and Survivin Protein in the Human Brain Astrocytomas

Objective To explore the expression and significance of STAT3 and Survivin protein in the human astrocytomas. Methods Expression level of STAT3 ,phosphorylated STAT3 （ P-STAT3 ） and Survivin protein was investigated by immunohistochemistry Enivision method in 53 cases of the human astrocytomas. Results The expression of STAT3 ,P-STAT3 and Survivin protein in the human astrocytomas tissue were significantly higher than those in the normal brain tissue （P 〈 0.01 ）. The expression of STAT3 ,P-STAT3 and Survivin protein were correlated with the histological grade, but not with sex ,age and location of the tumor. There were a positive correlation between the positive expression rate of STAT3 ,P-STAT3 and Survivin protein in the human astrocytomas tissue（ γs = 0. 431 ,P 〈 0.01 ;γs = 0.416 ,P 〈 0.01 ）. Conclusion Over-expression of STAT3 and Survivin may play an important role in tumorigenesis and progression of the human astrocytomas.