| 经皮给药系统促渗方法研究的新进展 |
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| 引用本文： | 韩璐,胡晋红,朱全刚.经皮给药系统促渗方法研究的新进展[J].中国新药杂志,2007,16(4):274-278. |
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| 作者姓名： | 韩璐 胡晋红 朱全刚 |
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| 作者单位： | 1. 同济大学附属东方医院药剂科,上海,200120
2. 第二军医大学长海医院药学部,上海,200433 |
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| 摘 要： | 促渗方法的发展对于经皮给药的研究意义重大。笔者从化学促渗技术，包括化学促渗剂、前体药物、传递体、含醇脂质体、非离子表面活性剂脂质体和微乳；以及物理促渗技术，包括离子导入、电致孔、超声波促渗、微针、照相波、热致孔和磁场导入等诸多方面综述了近年来经皮给药促渗方法研究的新进展。
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| 关 键 词： | 经皮给药 化学促渗技术 物理促渗技术 |
| 文章编号： | 1003-3734（2007）04-0274-05 |
| 收稿时间： | 2005-07-08 |
| 修稿时间： | 2005-07-08 |
Advances on enhancement of permeability by transdermal drug delivery |
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| HAN Lu,HU Jin-hong,ZHU Quan-gang.Advances on enhancement of permeability by transdermal drug delivery[J].Chinese Journal of New Drugs,2007,16(4):274-278. |
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| Authors: | HAN Lu HU Jin-hong ZHU Quan-gang |
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| Institution: | 1. Department of Pharmacy, Shanghai East Hospital Affiliated to Tongji University, Shanghai 200120, China; 2. Department of Pharmacy, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China |
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| Abstract: | The enhancement of drugs transfer through membrane is boosting the improvements of transdermal drug delivery. This article reviews current status and trends of chemical enhancing permeation techniques including chemical enhancer, prodrug, transomes, ethosomes, niosomes and microemulsion as well as physical enhancing permeation techniques including iontophoresis, electroporation, sonophoresis, microneedle, photomechanical wave, thermal poration and magnetophoresis. |
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| Keywords: | transdermal drug delivery chemical enhancing permeation techniques physical enhancing permeation techniques |
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