阿奇霉素联合小剂量激素对肺炎支原体大叶性肺炎的疗效观察

目的观察阿奇霉素联合小剂量激素对小儿肺炎支原体大叶性肺炎的临床疗效。方法选择开封市第二人民医院收治的肺炎支原体大叶性肺炎患儿63例,其中治疗组32例,对照组31例。两组均给予阿奇霉素联合二、三代头孢菌素治疗1~2周,治疗组在此基础上给予地塞米松0.2~0.3mg/（kg·d）静脉注射,连用5 d。观察两组患儿症状、体征恢复时间及C-反应蛋白、血沉变化。结果治疗组发热持续时间、咳嗽缓解时间、胸片阴影消退时间、肺部啰音消失时间分别为（5.19±1.57）d、（8.03±1.80）d、（2.80±0.74）周、（9.72±2.32）d,对照组分别为（7.32±2.14）d、（10.22±2.39）d、（3.52±0.87）周、（11.55±1.52）d,差异具有统计学意义（P〈0.01）;治疗组CRP、ESR水平分别为（6.08±1.70）mg/L、（20.00±5.81）mm/h,对照组分别为（10.28±2.97）mg/L、（28.16±6.47）mm/h,差异具有统计学意义（P〈0.01）。结论阿奇霉素联合小剂量地塞米松治疗肺炎支原体大叶性肺炎疗效显著,可有效缓解临床症状、缩短病程。

Efficacy of azithromycin combined with low-dose hormone in treatment of mycoplasma pneumoniae lobar pneumonia

【Objective】To observe the clinical efficacy of azithromycin combined with low-dose hormone in treatment of mycoplasma pneumoniae lobar pneumonia in children.【Methods】 Sixty-three pediatric patients with mycoplasma pneumoniae lobar pneumonia were divided into the control group and the treatment group,thirty-two pediatric patients in treatment group and thirty-one pediatric patients in control group.Azithromycin combined with second or third generation cephalosporin were given to both group,treatment for 1-2 weeks.On this basis,dexamethasone injection 0.2-0.3 mg/（kg ·d） were given to the treatment group,once every five days.The recovery time of symptoms and signs in both group, and the diversification of CRP and ESR were observed.【Results】Duration of fever（5.19±1.57） d vs（7.32±2.14） d and cough disappeared time（8.03±1.80） d vs（10.22±2.39） d and chest X-ray shadow absorption time（2.80±0.74） week vs（3.52±0.87）week and pulmonary rales disappeared time（9.72±2.32） d vs（11.55±1.52） d in the treatment group were less than those in the control group（P〈0.01）;CRP level（6.08±1.70） mg/L vs（10.28±2.97） mg/L and ESR level（20.00±5.81） mm/h vs（28.16±6.47） mm/h in the treatment group were less than those in the control group（P〈0.01）. 【Conclusion】Azithromycin combined with low-dose dexamethasone have significant effects in the treatment of pediatric patients with mycoplasma pneumoniae lobar pneumonia, can effectively relieve symptoms and shorten the course.