急性脑梗死患者血浆D-二聚体与纤维蛋白原的变化

目的　观察急性脑梗死患者血浆中D 二聚体和纤维蛋白原的变化 ,并探讨其临床意义。方法　采集 5 3例发病 2 4h内急性脑梗死患者血液 ,测定其血浆中D 二聚体和纤维蛋白原含量 ,并与 4 0例健康对照组比较。结果　急性脑梗死患者血浆D 二聚体 ,纤维蛋白原含量明显高于对照组 (P <0 0 1) ,并与梗死灶大小及病情轻重明显相关。结论　急性脑梗死患者存在凝血纤溶系统异常 ,血浆D -二聚体及纤维蛋白原检测对脑梗死患者的诊断及病情判断、溶栓的效果评价及预后有重要的参考价值。

The dynamic changes of plasma D-dimer and fibrinogen in patients with acute cerebral infarction

Objective To observe the changes of plasma D-dimer and fibrinogen and investigate its clinical significance in patients with acute cerebral infarction.Methods The blood samples of 53 acute cerebral infarction patients within 24 hours of onset was collected,the content of D-dimer and fibrinogen were determind,and compared with control group.Results In patients with acute cerebral infarction,the plasma contents of D-dimer and fibrinogen were significantly higher than those in control group(P<0.01).The levels of D-dimer and fibrinogen were significantly correlated with the infarction size and severity of disease.Conclusion There are some abnormalities in coagulative and fibrinolytic system in patients with acute cerebral infarction.The levels of plasma D-dimer and fibrinogen are useful for the diagnosis,evaluation of disease severity and effective evaluation of thrombolysis therapy,and judgment of prognosis in these patients.