生长抑素 SMS201-995 对小鼠结肠腺癌肝转移瘤的实验研究

目的本研究观察生长抑素衍生物ＳＭＳ２０１┐９９５对ＢＡＬＢ／ｃ小鼠结肠腺癌（ＣＴ２６）肝转移瘤细胞周期的影响，检测血清ＣＥＡ水平的变化，并观察小鼠生存期的改变。方法采用流式细胞术。结果与对照组相比，ＳＭＳ２０１┐９９５治疗组的瘤细胞增殖指数和Ｓ期细胞百分比明显降低（Ｐ＜０．０１），而Ｇ０／Ｇ１期细胞百分比则明显增加（Ｐ＜０．０１）。治疗组血清ＣＥＡ水平较对照组显著降低（Ｐ＜０．０５），生存期明显延长。治疗组细胞增殖指数，Ｓ期和Ｇ０／Ｇ１期细胞百分比与血清ＣＥＡ的变化密切相关（相关系数与Ｐ值分别为：ｒ＝０．６６７７，Ｐ＜０．０５；ｒ＝０．７１７０，Ｐ＜０．０１；ｒ＝－０．６７０３，Ｐ＜０．０５）。结论ＳＭＳ２０１┐９９５对结肠腺癌（ＣＴ２６）肝转移性肿瘤的生长具有一定的抑制作用。

INFLUENCE OF SOMATOSTATIN ANALOGUE SMS 201 995 ON CELL CYCLE AND SERUM CEA IN MICE BEARING HEPATIC METASTASES OF COLONIC ADENOCARCINOMA

Objective:Influence of growth inhibitor somatostatin analogue SMS 201 995 on the tumor cell cycle of hepatic metastases from colonic adenocarcinoma (CT 26) in BALB/c mice and on the serum CEA level were studied.Methods:The experiment was investigated by flow cytometry. Results: After treated with SMS 201 995,the proliferative index (PI) and the S phase percentage in hepatic tumor decreased significantly but the G 0/G 1 phase percentage incresased markedly in comparison with control ( P <0 01),the serum CEA level was lower,the survival time of treated group prolonged. The changes of PI,the percentage distribution of S phase and G 0/G 1 phase in cell cycle were closely related with the levels of serum CEA. Conclusions:SMS 201 995 may be useful for inhibiting the growth of CT26 colonic carcinoma.