| HPLC法测定双嘧达莫缓释片的含量 |
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| 引用本文： | 朱旭,高志祥,王琳,陈秋晨,刘雅茹,孟繁浩. HPLC法测定双嘧达莫缓释片的含量[J]. 实用药物与临床, 2010, 13(3): 193-194 |
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| 作者姓名： | 朱旭 高志祥 王琳 陈秋晨 刘雅茹 孟繁浩 |
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| 作者单位： | 中国医科大学药学院,沈阳,110001 |
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| 摘 要： | 目的建立高效液相色谱法测定双嘧达莫缓释片的含量。方法采用EclipseXDBC18(Agi-lent,4.6mm×150mm,5μm)色谱柱。流动相为甲醇:水:磷酸:二乙胺(275:225:0.3:0.1);流量:1.0mL/min;检测波长:283nm;进样量:20μL。结果双嘧达莫在0.16～1.6μg范围内线性关系良好(r=0.9995),平均回收率为100.63%,RSD=0.35%(n=9)。结论本方法简便易行,结果准确可靠,专属性强,适用于双嘧达莫缓释片含量的测定。
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| 关 键 词： | 双嘧达莫缓释片 高效液相色谱法 含量测定 |
Determination of dipyridamole sustained-release tablets by HPLC |
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| ZHU Xu,GAO Zhi-xiang,WANG Lin,CHEN Qiu-chen,LIU Ya-ru,MENG Fan-hao. Determination of dipyridamole sustained-release tablets by HPLC[J]. Practical Pharmacy and Clinical Remedies, 2010, 13(3): 193-194 |
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| Authors: | ZHU Xu GAO Zhi-xiang WANG Lin CHEN Qiu-chen LIU Ya-ru MENG Fan-hao |
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| Abstract: | Objective To establish an HPLC method for the determination of dipyridamole in dipyridamole sustained-release tablets.Methods Samples were separated on Eclipse XDB C18 column(Agilent,4.6 mm×150 mm,5 μm)using methanol-water-phosphate acid-diethylamide(275:225:0.3:0.1)as the mobile phase at a flow rate of 1 mL/min.The detective wavelength was set at 283 nm and the sample size was 20 μL.Results The dipyridamole had good liner relationship in 0.16～1.6 μg/mL(r=0.999 5),and the average recovery was 100.63%,RSD=0.35%.Conclusion This method was simple,rapid,accurate and precise. |
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| Keywords: | Dipyridamole sustained-release tablets HPLC Determination |
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