| 子痫前期患者IGF-1水平与围产儿结局的相关性研究 |
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| 引用本文： | 丁华,黄丽萍,刘和录,张荣贵,梁巧玲. 子痫前期患者IGF-1水平与围产儿结局的相关性研究[J]. 实用预防医学, 2010, 17(4): 654-656 |
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| 作者姓名： | 丁华 黄丽萍 刘和录 张荣贵 梁巧玲 |
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| 作者单位： | 广州医学院附属深圳沙井医院,广东,深圳,518104 |
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| 基金项目： | 深圳市宝安区科研立项项目 |
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| 摘 要： | 目的探讨子痫前期患者IGF-1水平与围产儿结局的相关性。方法选择正常晚期孕妇28例为对照组,轻、重度子痫前期孕妇各15例为研究组,分别于分娩前抽取孕妇静脉血,分娩时留取新生儿脐静脉血和羊水,同时记录新生儿出生体重、Apgar评分及胎盘重量等,应用酶联免疫吸附试验(ELISA),检测孕妇血、脐血及羊水中IGF-1水平,分析子痫前期中IGF-1水平与围产儿结局的相关性。结果(1)随着子痫前期病情严重程度的增加,IGF-1水平呈下降趋势,重度子痫前期组IGF-1水平明显低于轻度子痫前期组,轻度子痫前期组明显低于正常对照组,统计结果差异有统计学意义(P0.01)。(2)随着IGF-1水平的下降,重度子痫前期的新生儿出生时平均体重、Apgar评分、胎盘重量均显著低于正常对照组,统计结果差异有统计学意义(P0.01);FGR发生率、围产儿死亡率明显高于正常对照组,其结果差异有统计学意义(P0.01)。结论子痫前期患者IGF-1水平变化为胎儿预后提供了一种监测手段,重度子痫前期IGF-1水平显著降低,并且围产儿不良结局发生率较高。
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| 关 键 词： | 子痫前期 孕妇血 脐血 羊水 胰岛素样生长因子Ⅰ 围产儿结局 |
Correlation Between IGF-1 Level and Perinatal Outcome in Patients with Preeclampsia |
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| DING Hua,HUANG Li-ping,LIU He-lu,et al.. Correlation Between IGF-1 Level and Perinatal Outcome in Patients with Preeclampsia[J]. Practical Preventive Medicine, 2010, 17(4): 654-656 |
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| Authors: | DING Hua HUANG Li-ping LIU He-lu et al. |
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| Affiliation: | DING Hua,HUANG Li-ping,LIU He-lu,et al.(Shenzhen Shajing Affiliated Hospital of Guangzhou Medical University,Shenzhen 518104,Guangdong,China) |
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| Abstract: | Objective To investigate the correlation between IGF-1 level and perinatal outcome in patients with preeclampsia.Methods Twenty-eight cases of normal late pregnant women were selected as control group,and 30 cases of pregnant women with mild (n=15) and severe (n=15) preeclampsia were analyzed as study group.Venous blood of pregnant women was collected before delivery.Umbilical cord blood and amniotic fluid were collected.Neonatal birth weight,Apgar score and placental weight were recorded simultaneously.IGF... |
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| Keywords: | Preeclampsia Maternal blood Umbilical cord blood Amniotic fluid Insulin-like growth factor-Ⅰ Perinatal outcome |
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