乳腺浸润性导管癌中cyclinD1 、p57 KIP2的表达及意义

 目的 研究cyclinD1、p57^KIP2在乳腺浸润性导管癌（IDC）中的表达及意义。方法 采用免疫组织化学SP法检测64例113（2、15例乳腺导管内癌（DCIS）和15例癌旁正常乳腺组织中cyclinD1、p57 ^KIP2的表达。结果 cyclinD1、p57 ^KIP2阳性表达率在IDC与在乳腺不同组织之间、腋窝淋巴结有无转移之间差异均有显著性（P≤0．05，P〈0．01）；cyclinD1阳性表达率与IDC组织学分级有关（P〈0．01）；cyclinD1与p57 ^KIP2之间阳性表达率呈负相关（P〈0．01）。结论 cyclinD1与p57 ^KIP2共同参与了乳腺癌的发生发展过程。cyclinD1异常表达是乳腺癌发生的早期事件。联合检测cyclinD1及p57 ^KIP2对预测乳腺癌淋巴结转移有重要意义。

Expression and Their Clinical Significance of cyclin D1,and p57KIP2 in Invasive Duct Carcinoma of the Breast

Objective 　To study the expression cyclinD1 ,and p57^KIP2 in invasive duct carcinoma ( IDC) and their clinical significances. Methods 　In 64 IDC ,15 ductal carcinoma in situ (DCIS) ,and 15 adjacent normal breast tissues ,the expression of cyclinD1 ,and p57 ^KIP2was detected respectively by immunohistochemical SP methods. Results 　The expression of cyclinD1 and p57^KIP2 between IDC and breast different tissues ,and axilliaris lymph node metastasis ,and expression of cyclinD1 and histological grade of IDC had significant difference ( P ≤0. 05 , P < 0. 01) . There was negative relationship between expression of cyclinD₁ and p57 ^KIP2( P < 0. 01) . Conclusion 　cyclinD₁ and p57 ^KIP2may play an important role in the mammary tissue carcinogenesis and progression of breast carcinoma. The abnormal expression of cyclinD₁ was early event of breast carcinoma. The combined detection of cyclinD₁ and p57^KIP2has positive effects on predicting the lymph node metastasis in breast carcinoma.