Antipyrine elimination in critically ill patients |
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| Authors: | L. Mirvis Dr. N. Buchanan C. Eyberg |
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| Affiliation: | (1) Intensive Care Unit, P. O. Bertsham, 2013;(2) Metabolic and Nutrition Research Unit, Baragwanath Hospital, Johannesburg, South Africa |
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| Abstract: | Antipyrine kinetics were studied in 12 critically ill patients. Antipyrine half life was found to be short (6.5±3.4 h), this did not alter over 4 days of acute illness, although there was a tendency for antipyrine clearance to decrease over that time period. The need for further pharmacological studies in critically ill patients is stressed. |
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| Keywords: | Antipyrine kinetics hepatic microsomal oxidation critically ill patients |
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