Synthesis of furodiketochroman and bis-furocoumarin derivatives and their biological activity |
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| Authors: | O. H. Hishmat O. A. El-Shabrawy H. I. El Diwani N. M. Fawzy |
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| Affiliation: | 1. Natural Products Department, National Research Centre, Dokki, Cairo, Egypt
2. Pharmacology Department, National Research Centre, Dokki, Cairo, Egypt
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| Abstract: | A number of substituted furodiketochroman derivatives (III a-f ) have been synthesized by fusion of aromatic aldehydes with 5-hydroxybergapten and 5-hydroxyisopimpinellin. On the other hand, when the reaction was carried out in a solvent, the corresponding bis-furocoumarin derivatives (IV c-n ) were obtained. The anticoagulant effect of compoundsIII a,b,d andIV b,c,f,g,i,k , was tested. They failed to demonstrate any significant effect. The effect of the tested compounds on the arterial blood pressure was studied. CompoundsIV c ,III d ,III b ,IV b ,IV g ,IV k andIV i showed lowering effects on the normal systolic blood pressure of anaesthetized rats in a decreasing manner. |
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