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A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Abeta-inhibition of the cascade in cultured rat CNS neurons |
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| Authors: | Al Rahim Md Nakajima Akira Misawa Norihiko Shindo Kazutoshi Adachi Kyoko Shizuri Yoshikazu Ohizumi Yasushi Yamakuni Tohru |
| Affiliation: | Department of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Sendai, Japan. |
| Abstract: | |
| Keywords: | Chalcone-diol Aβ [amyloid β -peptide] ERK [extracellular signal-regulated kinase] CREB [cAMP-response element-binding protein] CNS [central nervous system] neuronal culture |
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