大鼠脑出血后体感诱发电位的改变与脑水肿的形成

目的:使用体感诱发电位(SEP)对脑出血(ICH)模型进行评价,并观察ICH后不同时期脑水肿的形成过程。方法:采用脑立体定向术制备大鼠脑内囊出血的模型。观察大鼠在手术前及手术后不同时期内神经系统功能、SEP、脑组织形态学及脑组织含水量的改变。结果:与假手术组相比,实验组(6h、12h、1d、5d)、各波潜伏期延长(P<0.05),脑组织含水量增多(P<0.05);实验组(2d、3d)各波潜伏期明显延长(P<0.01),脑组织含水量明显增多(P<0.01);实验组(7d)各波潜伏期缩短(P>0.05),脑组织含水量减少(P>0.05)。脑组织形态学与神经系统功能呈现相应的改变。结论:SEP是评价脑立体定向术制备大鼠脑内囊出血模型的最客观指标,脑出血后脑水肿的形成是一个动态过程,SEP的改变与脑水肿的形成有直接的关系

The change of somatosensory evoked potentials and the development of cerebral edema after intracerebral hemorrhage in rats

Objective: To evaluate the model of intracerebral capsule hemorrhage with somatosensory evoked potentials(SEP),and observe the development of cerebral edema during different periods after intracerebral hemorrhage(ICH) in rats.Methods: The model of ICH was established with the stereotactic method.Regional cerebral morphology,SEP,nervous symptoms,brain water content were measured during different period before and after operation.Results: Compared with the sham group,latency of SEP were prolonged(P<0.05) in experiment group(6 h,12 h,1 d,5 d)and the brain water content increased(P<0.05);the latency of SEP(2 d,3 d) were prolonged significantly(P<0.01) and brain water content increased significantly(P<0.01);but the latency of SEP(7 d) were shortened(P>0.05) and brain water content decreased(P>0.05).Regional cerebral morphology and nervous symptoms altered correspondingly.Conclusion: SEP is the most objective index to evaluate the model of intracerebral capsule hemorrhage in rats with the stereotactic method.The development of cerebral edema after ICH is a consecutive course.There is a directive relationship between the change of SEP and development of cerebral edema.