| 熔融法制备布洛芬固体分散体 |
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| 引用本文： | 魏敏,关皎,徐璐,姚慧敏,李三鸣. 熔融法制备布洛芬固体分散体[J]. 沈阳药科大学学报, 2010, 27(1): 15-19 |
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| 作者姓名： | 魏敏 关皎 徐璐 姚慧敏 李三鸣 |
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| 作者单位： | 沈阳药科大学药学院; |
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| 摘 要： | 目的提高布洛芬的体外溶出速率。方法以亲水性Sylysia 730为载体,采用熔融法制备布洛芬-Sylysia 730固体分散体;利用体外溶出度实验确定熔融法制备固体分散体的制备条件;采用粉末X射线衍射法、差示扫描量热法、扫描电子显微镜分析法对制备的固体分散体进行物相鉴别。结果熔融法制备的布洛芬-Sylysia 730固体分散体中布洛芬均以非晶态存在于载体中。结论用Sylysia 730制备布洛芬固体分散体后显著提高了布洛芬的溶出速率,可进一步进行体内释药行为考察。
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| 关 键 词： | 固体分散体 布洛芬 熔融法 Sylysia730 |
| 收稿时间： | 2009-04-22 |
| 修稿时间： | 2009-06-22 |
Preparation of solid dispersions of ibuprofen with fine silica particles using the melt-mixing method |
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| WEI Min,GUAN Jiao,XU Lu,YAO Hui-min,LI San-ming. Preparation of solid dispersions of ibuprofen with fine silica particles using the melt-mixing method[J]. Journal of Shenyang Pharmaceutical University, 2010, 27(1): 15-19 |
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| Authors: | WEI Min GUAN Jiao XU Lu YAO Hui-min LI San-ming |
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| Affiliation: | WEI Min,GUAN Jiao,XU Lu,YAO Hui-min,LI San-ming (School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China) |
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| Abstract: | Objective To improve the dissolution of ibuprofen,a poorly water-soluble drug through the preparation of solid dispersions using melt-mixing method with hydrophilic silica particles(Sylysia).Methods The dissolutions of the ibuprofen-Sylysia730 solid dispersions in vitro were analyzed.Powder X-ray diffractometry differential scanning calorimetry and scanning electron microscope were used to characterize the solid dispersions.Results The results of in vitro dissolution indicated that the dissolubility of ibup... |
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| Keywords: | solid dispersion ibuprofen melt-mixing method Sylysia730 |
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