Efficacy of CLARA in recurrent/refractory acute myeloid leukaemia patients unresponsive to FLAG chemotherapy |
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| Authors: | Ali Hakan Kaya Emre Tekgündüz Kadir Ilkkiliç Mehmet Sinan Dal Alparslan Merdin Abdullah Karakus |
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| Affiliation: | 1. Hematology Clinic and Bone Marrow Transplantation Unit, University of Health Sciences Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkeydr.alihakan@gmail.com;3. Hematology Clinic and Bone Marrow Transplantation Unit, University of Health Sciences Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey;4. Department of Hematology, Faculty of Medicine, Pamukkale University, Denizli, Turkey;5. Department of Hematology, Faculty of Medicine, Dicle University, Diyarbak?r, Turkey |
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| Abstract: | We hereby report our multicentre, retrospective experience with CLARA in patients with fludarabine/cytarabine/G-CSF (FLAG) refractory AML. The study included all consecutive R/R AML patients, who received CLARA salvage during October 2010–October 2015 period. All patients were unresponsive to FLAG salvage chemotherapy regimen and did not undergo previous allo-HCT. A total of 40 patients were included. Following CLARA 5 (12.5%) patients experienced induction mortality and 10 (25%) patients achieved CR. 25 (62.5%) patients were unresponsive to CLARA. 7 (17.5%) out of 10 patients in CR received allo-HCT. Median overall survival of patients who achieved CR after CLARA was 24.5 months (8.5–54.5) and 3 months (2.5–5), in patients who underwent and didn’t allo-HCT, respectively. Our results indicate that CLARA may be good alternative even in FLAG refractory AML patients and can be used as a bridge to allo-HCT, who have a suitable donor and able to tolerate the procedure. |
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| Keywords: | Acute myeloid leukaemia AML Relapse Refractory Clofarabine |
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