nm 23-H1 和LN-R 与胆管癌淋巴结转移关系的研究

 目的　探讨人胆管癌细胞中 nm2 3- H1和 LN- R的表达水平与胆管癌转移的关系。方法　应用 S- P免疫组化法对 5 2例人胆管癌细胞中 nm2 3- H1和 LN- R的表达水平进行研究。结果nm2 3- H1低表达及 LN- R高表达与胆管癌淋巴结转移呈明显相关 (P<0 .0 5 ) ;并且其表达与胆管癌组织学类型、分化程度亦存在明显相关 (P<0 .0 5 )。结论　nm2 3- H1低表达和 LN- R高表达 ,在胆管癌的淋巴转移中起重要作用。

The Relation Betweennm23,LN-R and Lymph Node Metastasis of Cholangiocarcinomas

Objective Study the correlation of the expression of nm23|H1 and LN|R with the biologic behavior and lymph node metastasis in the cholangiocarcinomas.Methods Using S|P immunohistochemical methods.Results There were significant differences among different histopathological types and degrees of differentation of nm23|H1 and LN|R (P<0.05) .nm23|H1 low expression tumours were associated with a higher incidence of metastasis to lymph nodes than were nm23|H1 normal expressive (P<0.05) .The metastatic rate of tumours stained positively for LN|R were higher than in those with negative LN|R staining (P<0.05) .Conclusion It is suggested that nm23|H1 low|expression and LN|R overexpression might play signficant role in lymph node metastasis in the cholangiocarcinomas.