| 皮肤创面组织VEGF和MMP-2的表达及意义 |
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| 引用本文： | 刘文忠,恩和吉日嘎拉,康毅敏,汪剑威.皮肤创面组织VEGF和MMP-2的表达及意义[J].内蒙古医学院学报,2009,31(2). |
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| 作者姓名： | 刘文忠 恩和吉日嘎拉 康毅敏 汪剑威 |
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| 作者单位： | 1. 内蒙古医学院,人体解剖学教研室,内蒙古,呼和浩特,010059
2. 内蒙古医学院基础医学院 |
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| 基金项目： | 内蒙古自治区高等学校科学研究项目 |
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| 摘 要： | 目的：探讨在皮肤烫伤创面愈合过程中血管内皮生长因子（VEGF）和基质金属蛋白酶-2（MMP-2）的表达及意义。方法：将大鼠制作深Ⅱ度烫伤创面,在各时间点活杀取材,采用原位杂交和免疫组织化学方法检测VEGF、MMP-2的表达,以正常皮肤作为对照。结果：（1）原位杂交显示正常皮肤VEGF有微弱表达,在伤后30m in开始创缘真皮内毛囊、皮脂腺、血管内皮细胞及成纤维细胞内阳性颗粒增加;伤后3d表达进一步增多,伤后7d减弱;（2）MMP-2免疫组化染色显示正常皮肤有微弱表达。烫伤后阳性细胞逐渐增多,表达程度加强。伤后1d在真皮层内的成纤维细胞、血管内皮细胞及血管周围渗出的炎性细胞内有表达。伤后3d表达进一步增强,持续到伤后7d,伤后14d表达减弱。结论：VEGF在皮肤烫伤创面愈合过程中可能通过对MMP-2的活性调节途径调控内皮细胞结构和增殖等功能。
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| 关 键 词： | 烫伤皮肤 VEGF MMP-2 表达 |
EXPRESSIONS OF MMP-2 AND VEGF IN SCALD TISSUES OF INJURY SKIN AND ITS SIGNIFICANCE |
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| LIU Wen-zhong,Enhejirigala,KANG Yi-min,et al..EXPRESSIONS OF MMP-2 AND VEGF IN SCALD TISSUES OF INJURY SKIN AND ITS SIGNIFICANCE[J].Acta Academiae Medicinae Neimongol,2009,31(2). |
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| Authors: | LIU Wen-zhong Enhejirigala KANG Yi-min |
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| Institution: | LIU Wen-zhong,Enhejirigala,KANG Yi-min,et al.(Department of Anatomy,Inner Mongolia Medical College,Hohhot 010059 China) |
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| Abstract: | Objective:To explore the expressions of vascular endothelial growth factor(VEGF)and matrix metalloproteinase-2(MMP-2)in scald skin and evaluate its significance.Methods:Rats were anesthetized,and then scald injured rats were killed in different time points and specimens were collected.The hybridization in situ and immunohistochemical method(two-step method)were used to evaluate the expression of VEGF and MMP-2 in scald skin and normal skin the correlations were analysed.Results:(1)VEGF was weakly expressed ... |
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| Keywords: | VEGF MMP-2 |
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