Effects of propranolol on β- Adrenergic receptor of experimental acute myocardial infarction in rats |
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Authors: | Liu Zhengxiang Liu Xiaochun Zhang Jian Ouyang Xingbiao Guan Xinmin |
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Institution: | (1) Department of Cardiology, Tongji Hospital, Tongji Medical University, 430030 Wuhan;(2) Department of Neurobiology, Tongji Medical University, 430030 Wuhan |
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Abstract: | Summary By using receptor autoradiography to observe the distribution and density of receptors, the effects of propranolol, a β-blocker,
on β-adrenergic receptor of experimental acute myocardial infarction (AMI) were studied. One week after ligation of proximate
left anterior descend (LAD) coronary artery, 3H] DHA binding sites were markedly decreased in both infarctregion and non-infarct region. After treatment of propranolol
(100 μg/kg), the 3H] DHA binding sites were obviously increased in the infarct region, and they were further decreased in the non-infarct region.
The ratio of 3H] DHA binding sites of the infarct region to non-infarct region was from 0. 24 at LAD ligation to 0. 87 after propranolol
treatment, which was close to 0. 97 of control group (sham operation). The results indicated that the propranolol acted directly
on myocardial β- adrenergic through the receptor regulation of the balance of β-receptors between the infarct region and non-infarct
region, and improvement of the myocardial consonation and contraction synergism, thereby protecting the heart affected by
AMI. |
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Keywords: | acute myocardial infarction propranolol β -adrenergic receptor autoradiography |
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