p27蛋白在结肠直肠癌中的表达与预后的关系

背景与目的：有研究表明p27蛋白在组织中表达水平的高低与某些肿瘤的预后有关,本研究拟探讨p27蛋白在结肠直肠癌中的表达水平与预后的关系。方法;用免疫组化法检测p27蛋白在82例结肠直肠癌中的表达水平。然后用X^2检验检测其与临床病理学特征的关系,Log rank检验p27蛋白的表达与生存时间的关系。Cox回归模型作单因素和多因素预后分析。结果：p27蛋白在结肠直肠癌中的高表达率为53.66%(44/82),低表达率为46.34%(38/82),p27蛋白低表达与肿瘤在肠壁的深浸润及淋巴结转移显著相关;Log rank检验发现p27蛋白的表达与结肠直肠癌患者的生存期呈正相关。Cox模型则显示p27蛋白可作为结肠直肠癌的一个预后指标。结论：p27蛋白低表达与肿瘤在肠壁的深浸润,易发生淋巴结转移,预后差,生存期短显著相关,p27蛋白高表达则相反,p27蛋白可作为结肠直肠癌患者预后的一个独立指标。

Relationship between p27 expression and prognosis of colorectal carcinoma

BACKGROUND & OBJECTIVE: It has been reported that p27 is associated with prognosis of some tumor. This study was designed to investigate the relationship between expression of p27 and prognosis of colorectal carcinoma. METHODS: The expression of p27 in 82 colorectal carcinoma specimens was detected by immunohistochemical method. The relationship between the expression of p27 and clinicopathological characteristics or survival time was analyzed by chi 2 test or log rank test, respectively, while univariate and multivariate prognostic analyses were performed by using Cox regression model. RESULTS: High p27 expression rate in colorectal carcinoma was 53.66% (44/82), while low expression rate was 46.34% (38/82). Low p27 expression in colorectal carcinoma was significantly associated with late Dukes stage, high incidence of lymph metastasis, and distant metastasis. Long rank test showed that the p27 expression was positively correlated to survival time and Cox regression indicated that the p27 was an prognostic marker of colorectal carcinoma. CONCLUSION: Low p27 expression in colorectal carcinoma was significantly associated with late Dukes stage, high incidence of lymph metastasis, and distant metastasis, poor prognosis, and short survival time. p27 is an prognostic marker of colorectal carcinoma.