| 急性白血病细胞Rb蛋白表达的研究 |
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| 引用本文： | 鹿全意,林茂芳. 急性白血病细胞Rb蛋白表达的研究[J]. 浙江大学学报(医学版), 1997, 0(6) |
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| 作者姓名： | 鹿全意 林茂芳 |
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| 作者单位： | 浙江医科大学附属第一医院血液科!河南省人民医院(鹿全意)，浙江医科大学附属第一医院血液科(林茂芳) |
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| 摘 要： | 作者用免疫组化方法检测了40例急性白血病细胞中Rb基因蛋白的表达情况，结果发现，Rb蛋白表达缺失率为37．5％，以M_5亚型多见，占41．6％。结果表明，Rb基因表达状态与急性白血病的类型有关，并影响患者的疗效和预后。
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| 关 键 词： | 白血病／诊断 预后 视网膜神经胶质瘤基因 免疫测定 |
Rb PROTEIN EXPRESSION IN ACUTE LEUKEMIA CELLS AND ITS CLINICAL SIGNIFICANCE |
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| Lu Quanyi, Lin Maofang. Rb PROTEIN EXPRESSION IN ACUTE LEUKEMIA CELLS AND ITS CLINICAL SIGNIFICANCE[J]. Journal of Zhejiang University. Medical sciences, 1997, 0(6) |
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| Authors: | Lu Quanyi Lin Maofang |
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| Abstract: | Rb Protein expression of leukemia cells was examined by SABC immunohistochemistry in 40 patients with acute leukemia. Results showed that Rb protein negative expression rate was 37. 5% in all patients (15/40),and 41. 6% in patients with M5 subtype of leukemia(5/12). This suggested that Rb gene expression might be associated with subtypes of leukemia and would af fect results of chemotherapy and the prognosis of the disease. |
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| Keywords: | Leukemia/diag prognosis Genes Retinoblastoma Immunoassay |
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