大于胎龄儿脐血脂联素水平测定及意义

目的探讨血脂联素水平与大于胎龄儿的关系。方法选取大于胎龄儿（LGA）和适于胎龄儿（AGA）各30人。应用酶联免疫吸附法测定脐血和母血脂联素浓度,用免疫比浊法测定血脂水平;并分析脐血脂联素水平与母血脂联素、新生儿性别、出生体质量、体质指数（BMI）、胎盘重量和血脂水平的相关性。结果大于胎龄儿脐血浆脂联素水平低于适于胎龄儿,差异有统计学意义（P〈0.01）;2组新生儿血脂水平差异无统计学意义（P〉0.05）。大于胎龄儿血浆脂联素水平与新生儿出生体质量、BMI、胎盘重量、脐血甘油三酯水平均呈显著负相关（r分别为-0.848,-0.785,-0.835,P〈0.001）。大于胎龄儿男婴和女婴脐血浆脂联素、血脂各成分水平比较,差异均无统计学意义（P〉0.05）。结论血脂联素水平的变化与大于胎龄儿的发生有关,测定脐血脂联素水平有助于判断大于胎龄儿的发展趋势。

Adiponectin level of cord blood in LGA infants and its possible clinical significance

Objective To investigate the levels of cord plasma adiponectin in large for gestational age infants and to explore its clinical significance.Methods In the present study,30 LGA infants and 30 appropriate AGA infants were enrolled in.Puerpera and cord plasma adiponectin was determined with ELISA.Blood lipids were assayed with turbidimetry.The correlation between cord plasma adiponectin and puerpera plasma adiponectin,maternal plasma adiponectin,newborn gender,birth weight,BMI,placental weight and blood lipids were analyzed.Results(1)Compared with AGA group,cord plasma adiponectin in LGA infants decreased significantly(P<0.01),and blood lipids change slightly(P>0.05).(2)The adiponectin in LGA infants inversely correlated with birth weight,newborn BMI,placental weight and the cord blood TG levels(r=-0.848,-0.785,-0.835,all P<0.001).(3)Adiponectin and lipid components in cord blood have no difference between male and female neonates(P>0.05).Conclusion Alteration in plasma adiponectin correlated with LGA infants.It may apply to estimate the developing of LGA infants.