The effect of moderate alcohol consumption on adiponectin oligomers and muscle oxidative capacity: a human intervention study |
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| Authors: | J W J Beulens L J C van Loon F J Kok M Pelsers T Bobbert J Spranger A Helander H F J Hendriks |
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| Institution: | (1) TNO Quality of Life, Business Unit Biosciences, Utrechtseweg 48, 3704 HE Zeist, P.O. Box 360, 3700 AJ Zeist, The Netherlands;(2) Department of Human Nutrition, Wageningen University, Wageningen, The Netherlands;(3) Department of Movement Sciences, Maastricht University, Maastricht, The Netherlands;(4) Department of Clinical Nutrition, German Institute of Human Nutrition Postdam-Rehbruecke, Nuthetal, Germany;(5) Department of Endocrinology Diabetes and Nutrition, Charité-University Medical School Berlin, Berlin, Germany;(6) Alcohol Laboratory, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden |
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| Abstract: | Aims/hypothesis The aim of this study was to investigate whether moderate alcohol consumption increases plasma high molecular weight (HMW)
adiponectin and/or muscle oxidative capacity.
Materials and methods Eleven lean (BMI 18–25 kg/m2) and eight overweight (BMI ≥27 kg/m2) men consumed 100 ml whisky (∼32 g alcohol) or water daily for 4 weeks in a randomised, controlled, crossover trial. After
each treatment period, muscle biopsies and fasting blood samples were collected.
Results Adiponectin concentrations increased (p < 0.001) by 12.5% after 4 weeks of moderate alcohol consumption. Moderate alcohol consumption tended to increase HMW adiponectin
by 57% (p = 0.07) and medium molecular weight adiponectin by 12.5% (p = 0.07), but not low molecular weight (LMW) adiponectin. Skeletal muscle citrate synthase, cytochrome c oxidase and β-3-hydroxyacyl coenzyme A dehydrogenase (β-HAD) activity were not changed after moderate alcohol consumption,
but an interaction between alcohol consumption and BMI was observed for cytochrome c oxidase (p = 0.072) and citrate synthase (p = 0.102) activity. Among lean men, moderate alcohol consumption tended to increase cytochrome c oxidase (p = 0.08) and citrate synthase activity (p = 0.12) by 23 and 26%, respectively, but not among overweight men. In particular, plasma HMW adiponectin correlated positively
with activities of skeletal muscle citrate synthase (r = 0.64, p = 0.009), cytochrome c oxidase (p = 0.59, p = 0.009) and β-HAD (r = 0.46, p = 0.056), while such correlation was not present for LMW adiponectin. Whole-body insulin sensitivity and intramyocellular
triacylglycerol content were not affected by moderate alcohol consumption.
Conclusions/interpretation Moderate alcohol consumption increases adiponectin concentrations, and in particular HMW adiponectin. Concentrations of HMW
adiponectin in particular were positively associated with skeletal muscle oxidative capacity. |
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| Keywords: | Adiponectin High molecular weight adiponectin Insulin sensitivity Intramyocellular triacylglycerols Moderate alcohol consumption Muscle oxidative capacity |
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