VEGF-C在非小细胞肺癌淋巴结转移中的意义

目的 探讨血管内皮生长因子-C(vascular endothelial growth factor-c,VEGF-C)在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达及其与临床病理特征之间的关系.方法 采用免疫组化的方法检测80例NSCLC组织中VEGF-C及CD34的表达,分析VEGF-C和血管密度(microvessel density,MVD)、肿瘤组织类型、组织分化程度和淋巴结转移之间的关系.结果 VEGF-C的表达与非小细胞肺癌的病理类型密切相关,其中在腺癌中表达率最高(P=0.030 8);在术中淋巴结检测为阳性的病例,VEGF-C的表达明显增强,有统计学意义(P=0.024 6).VEGF-C的表达与肿瘤分化程度及肿瘤内新生血管密度无关.结论 VEGF-C促使肺癌内淋巴管形成,促进肺癌淋巴结转移;是肺癌淋巴管转移的预测性指标.

Significance of VEGF-C in non-small cell lung cancer with lymph node metastasis

Objective To study the relationship between VEGF-C expression and clinicopathologic characteristics of patients with non-small cell lung cancer(NSCLC). Methods VEGF-C and CD34 expressions were detected in 80 patients with NSCLC by immunohistochemical staining.The correlation of VEGF-C to microvessel density(MVD),histological type,differentiation and lymphatic metastasis were analyzed.Results The expression of VEGF-C correlated highly with histology,especially in adenocarcinoma(P=0.030 8) and lymphatic metastasis(P=0.024 6).The expression of VEGF-C protein was negatively related with the differentiation of NSCLC and MVD.Conclusion VEGF-C promotes intratumoral lymph angiogenesis and lymph node metastasis.The high expression of VEGF-C indicates high risk of lymphatic metastasis.