抗心磷脂抗体在梅毒诊断中的意义

目的探讨酶联免疫吸附试验（EuSA）检测抗心磷脂抗体（ACA）在梅毒诊断中的意义。方法ELISA检测梅毒患者ACA水平，同时检测不加热血清反应素玻片试验（USR）滴度，分析两者有无相关性；以尖锐湿疣和健康体检者为阴性对照，以USR为标准分析ELISA法检测ACA的准确性和敏感性。以抗核抗体阳性的结缔组织病（CTD）患者为阳性对照，比较两组之间ACA阳性率有无差别。结果USR和ELISA检测的ACA值之间相关系数为0．531，在0．01水平，有显著相关性。ELISA法检测ACA诊断梅毒的灵敏度67．4％，特异度90．9％。梅毒组和CTD组之间ACA阳性率差异有显著性。结论ELISA法检测ACA可作为梅毒患者诊断和疗效观察指标之一。

Significance of anticardiolipin antibody in diagnosing syphilis

Objective To evaluate the significance of ELISA technique for the detection of anticardiolipin antibody in the patients with syphilis.Methods The sera of 49 cases with syphilis were tested by ACA-ELISA and USR,respectively. The result was treated with correlation analysis.Sensitivity and specificity of the result of ACA-ELISA were analyzed by comparing the data with those of USR. In addition, the sera of 31 cases of CTD were tested by ACA-ELISA, and the result was compared with that of syphilis group.Results The correlation was significant at the 0.01 level(r=0.531). The indexes were 67.4% for sensitivity and 90.9% for specificity. The positive rate of ACA-ELISA in CTD groups was significantly different from that in syphilis groups(P<0.05). Conclusion Result of the sera of syphilis tested by ACA-ELISA is reliable indicator and may be applied in diagnosing the patients with syphilis and evaliating curative effect.