腹型肥胖男性糖耐量试验各时点血糖与代谢综合征各组份的相关性 |
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引用本文: | 刘波,尹福在,马春明,秦春梅,王锐,陆强. 腹型肥胖男性糖耐量试验各时点血糖与代谢综合征各组份的相关性[J]. 医学临床研究, 2011, 28(10): 1886-1888 |
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作者姓名: | 刘波 尹福在 马春明 秦春梅 王锐 陆强 |
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作者单位: | 河北省秦皇岛市第一医院内分泌科,河北,秦皇岛,066000 |
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摘 要: | [目的]探讨腹型肥胖男性葡萄糖耐量试验(OGTT)各时点血糖与代谢综合征各组份的相关性.[方法]选取 20~50岁糖耐量正常的男性为研究对象,其中腰围(WC)≥90 cm 36例为腹型肥胖组,WC〈90 cm 31例为对照组,行OGTT并检测血脂、肝肾功能及人体基本参数.[结果]两组间空腹血糖(FPG)和糖负荷后2 h血糖(2hPG)和3 h血糖(3hPG)比较无统计学差异(P〉0.05),腹型肥胖组糖负荷后 0.5 h血糖(0.5hPG),1 h血糖(1hPG)和葡萄糖曲线下面积(AUCglu)高于对照组(P〈0.05).其中 1hPG与WC(r=0.519),收缩压(SBP)(r=0.456),舒张压(DBP)(r=0.338),甘油三脂(TG)(r=0.439),高密度脂蛋白胆固醇(HDL-C)(r=-0.391),尿酸(UA)(r=0.418),AUCglu(r=0.914)和胰岛素抵抗指数(Homa-IR)(r=0.470)相关性最强(P〈0.01).多元线性回归显示,1hPG与WC、SBP、DBP、TG、HDL-C和UA存在独立相关.[结论]NGT腹型肥胖男性1hPG与多种代谢综合征组份密切相关.因此,在腹型肥胖人群进行OGTT时应更加关注1hPG监测
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关 键 词: | 肥胖症 葡糖耐量试验 血糖 代谢疾病 |
Relationship Between Blood Glucose Levels at Each Time Point of Oral Glucose Tolerance Test and the Components of Metabolic Syndrome in Abdominal Obese Men |
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Affiliation: | LIU Bo , YI N Fu-zai , MAChun-ming,et al ( Department of Endocrinology, First Hospital of Qinhuangdao City, Hebei 066000, China ) |
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Abstract: | [Objective] To explore the relationship between blood glucose levels at each time point of oral glucose tolerance test and the components of metabolic syndrome in abdominal obese men. [Methods]The men with normal glucose tolerance(NGT) aged 20-50 years old were enrolled in this study. The abdominal obese group included 36 cases with waist circumference ≥ 90cm, and the control group included 31 cases with waist circumference 〈 90cm. OGTT was used to measure the blood lipids, hepatic and renal function and anthropometric parameters. [Results] There was no significant difference in fasting plasma glucose(FPG), 2-hour postload plasma glucose(2hPG) and 3-hour postload plasma glucose(3hPG) between two groups( P 〉0.05). The 0.5-hour postload plasma glucose(0.5hPG),1-hour postload plasma glucose(lhPG) and glucose area under the curve(AUCglu) in abdominal obese group were higher than those in control group( P 〈0.05). The lhPG was closely positively correlated with waist circumference(WC) ( r = 0. 519), systolic blood pressure(SBP) ( r=0. 456), diastolic blood pressure(DBP) ( r =0. 338), triglycerides(TG)( r = 0. 439), high-density lipoprotein cholesterol(HDL-C)( r =-0.391 ), uric acid ( UA ) ( r =0.418 ), AUCglu ( r -0.914 ) and ins ulin resistance index( H OMA-IR ) ( r = 0.470) ( P〈0.01). Multiple linear regression analysis showed that lhPG was independently related to WC, SBP, DBP, TG, HDL-C and UA. [Conclusion] The lhPG is closely related with the components of metabolic syndrome in abdominal obese men with NGT. Therefore, when OGTT was performed for abdominal obese population, the moni- toring of lhPG should be paid more attention. |
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Keywords: | obesity glucose tolerance test blood glucose metabolic diseases |
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