腹型肥胖男性糖耐量试验各时点血糖与代谢综合征各组份的相关性

目的]探讨腹型肥胖男性葡萄糖耐量试验（OGTT）各时点血糖与代谢综合征各组份的相关性.方法]选取 20～50岁糖耐量正常的男性为研究对象,其中腰围（WC）≥90 cm 36例为腹型肥胖组,WC〈90 cm 31例为对照组,行OGTT并检测血脂、肝肾功能及人体基本参数.结果]两组间空腹血糖（FPG）和糖负荷后2 h血糖（2hPG）和3 h血糖（3hPG）比较无统计学差异（P〉0.05）,腹型肥胖组糖负荷后 0.5 h血糖（0.5hPG）,1 h血糖（1hPG）和葡萄糖曲线下面积（AUCglu）高于对照组（P〈0.05）.其中 1hPG与WC（r=0.519）,收缩压（SBP）（r=0.456）,舒张压（DBP）（r=0.338）,甘油三脂（TG）（r=0.439）,高密度脂蛋白胆固醇（HDL-C）（r=-0.391）,尿酸（UA）（r=0.418）,AUCglu（r=0.914）和胰岛素抵抗指数（Homa-IR）（r=0.470）相关性最强（P〈0.01）.多元线性回归显示,1hPG与WC、SBP、DBP、TG、HDL-C和UA存在独立相关.结论]NGT腹型肥胖男性1hPG与多种代谢综合征组份密切相关.因此,在腹型肥胖人群进行OGTT时应更加关注1hPG监测

Relationship Between Blood Glucose Levels at Each Time Point of Oral Glucose Tolerance Test and the Components of Metabolic Syndrome in Abdominal Obese Men

Objective] To explore the relationship between blood glucose levels at each time point of oral glucose tolerance test and the components of metabolic syndrome in abdominal obese men. Methods]The men with normal glucose tolerance（NGT） aged 20-50 years old were enrolled in this study. The abdominal obese group included 36 cases with waist circumference ≥ 90cm, and the control group included 31 cases with waist circumference 〈 90cm. OGTT was used to measure the blood lipids, hepatic and renal function and anthropometric parameters. Results] There was no significant difference in fasting plasma glucose（FPG）, 2-hour postload plasma glucose（2hPG） and 3-hour postload plasma glucose（3hPG） between two groups（ P 〉0.05）. The 0.5-hour postload plasma glucose（0.5hPG）,1-hour postload plasma glucose（lhPG） and glucose area under the curve（AUCglu） in abdominal obese group were higher than those in control group（ P 〈0.05）. The lhPG was closely positively correlated with waist circumference（WC） （ r = 0. 519）, systolic blood pressure（SBP） （ r=0. 456）, diastolic blood pressure（DBP） （ r =0. 338）, triglycerides（TG）（ r = 0. 439）, high-density lipoprotein cholesterol（HDL-C）（ r =-0.391 ）, uric acid （ UA ） （ r =0.418 ）, AUCglu （ r -0.914 ） and ins ulin resistance index（ H OMA-IR ） （ r = 0.470） （ P〈0.01）. Multiple linear regression analysis showed that lhPG was independently related to WC, SBP, DBP, TG, HDL-C and UA. Conclusion] The lhPG is closely related with the components of metabolic syndrome in abdominal obese men with NGT. Therefore, when OGTT was performed for abdominal obese population, the moni- toring of lhPG should be paid more attention.