335例鼻咽癌根治性放疗后晚期反应分析

目的 分析我院鼻咽癌患者根治性常规放疗后长期生存情况和晚期反应.方法 我院335例经病理证实为鼻咽癌的初治患者均接受根治性常规放疗,57.0％的患者接受顺铂+氟尿嘧啶为主的化疗.观察并记录患者的长期生存情况和晚期反应.结果 随访率92.2％,中位随访时间55(1～104)个月.全组5年总生存率、无进展生存率、无复发生存...

Late Toxicities After Definitive Conventional Radiotherapy for Nasopharyngeal Carcinoma:A Retrospective Analysis of 335 Patients in a Single Institute

Objective To summarize the survival of nasopharyngeal carcinoma after definitive conventional radiotherapy and the late toxicities in a single institute. Methods The 335 patients with histologically proven nasopharyngeal carcinoma were treated with definitive conventional radiotherapy,and 57.0% of the 335 patients were given with the cisplatin plus fluorouracil chemotherapy.The survival and late toxicities were observed. Results The follow-up rate was 92.2%,the median follow-up time was 55 months(1-104 months).The 5-year overall survival rate,progression-free survival rate,relapse-free survival rate and distant metastasis-free survival rate were 71.4%,61.3%,66.2% and 65.9%,respectively.The most common late radiation-related complications were xerostomia(100.0%),fibrosis(92.5%),trismus(71.0%),hearing loss(65.1%),dental caries and mouth extraction(39.4%),dysphagia(35.8%),voice changes(26.9%).The independent prognostic factors for radiation encephalopathy and radiation-induced lower cranial neuropathy were the dose to primary site and the T-staging. Conclusion Treatment results of definitive conventional radiotherapy for nasopharyngeal carcinoma in our institute were similar with the other centers at the same period,radiation encephalopathy should be prevented and treated in patients with higher dose to primary site and(or) advanced T-staging.