老年患者围术期血浆NE和Cor水平变化与术后认知功能障碍的关系

目的]观察老年患者围术期血浆去甲肾上腺素(NE)和皮质醇( Cor)水平变化,探讨其与术后认知功能障碍(POCD)的关系.方法]选择年龄≥60岁、全麻下择期行腹部手术患者60例,于麻醉诱导前5 min(T0)、手术开始后30 min(T1)、手术结束时(T2)、术后24 h(T3) 、术后48 h(T4)测定血浆N...

Relationship Between Postoperative Cognitive Dysfunction and the Changes of Plasma NE and Cor Concentration in Elderly Patients in Perioperative Period

Objective] To observe the changes of plasma norepinephrine（NE） and corticosteroid（Cor） concentration in elderly patients in perioperative period and explore their relationship with postoperative cognitive dysfunction（POCD）. Methods] Sixty patients more than 60 years old undergoing elective abdominal surgery were chosen. Plasma NE and Cor were measured at 5min before anesthesia induction（T0）, 30min after the beginning of surgery（T1 ）, at the end of surgery（T2 ）, 24h after surgery（T3 ） and 48h after surgery（T4 ）. POCD was evaluated. Plasma NSE and Cor concentration before and after surgery were compared between POCD group and non-POCD group. Results] In all 60 patients, plasma NE level increased at T1 and T2, and plasma Cor increased at T1 , T2 and T2. POCD occurred in 13 patients of all 60 elderly patients 1d after abdominal surgery. Plasma NE level at T2 in POCD group was higher than that in non-POCD group. Plasma Cor level at T2 and T3 in POCD group was higher than that in non-POCD group. Conclusion] POCD in elderly patients is closely related to the levels of plasma NE and Cor in perioperative period.