| Caveolin-1敲除对C57BL/6小鼠繁殖性能及子代离乳前体质量的影响 |
| |
| 引用本文： | 俞悦,易健,蔡光先,刘柏炎. Caveolin-1敲除对C57BL/6小鼠繁殖性能及子代离乳前体质量的影响[J]. 湖南中医药大学学报, 2011, 31(11): 7-8,15. DOI: 10.3969/j.issn.1674-070X.2011.11.002.007.02 |
| |
| 作者姓名： | 俞悦 易健 蔡光先 刘柏炎 |
| |
| 作者单位： | 湖南中医药大学省部共建教育部重点中医内科实验室,湖南长沙,410007 |
| |
| 基金项目： | 国家自然科学基金资助项目，教育部博士点专项科研基金资助项目，湖南省教育部重点资助项目，湖南省教育厅重点资助项目 |
| |
| 摘 要： | 目的探讨小窝蛋白Caveolin-1敲除对C57BL/6小鼠离乳前繁殖性能及体质量的影响。方法分别对Caveolin-1基因敲除小鼠和同源C57小鼠进行体质量、初产日龄、胎次间隔时间、平均产仔数及离乳存活率的观察及分析。结果 C57BL/6小鼠鼠仔平均体质量均高于Caveolin-1基因敲除鼠,在1、7、14 d时两者比较差异无统计学意义(P>0.05);21 d时,两者差异具有统计学意义(P<0.05);两组初产日龄、胎次间隔时间及平均产仔数差异无统计学意义(P>0.05),但C57BL/6小鼠离乳存活率明显高于基因敲除鼠,两者差异具有统计学意义(P<0.05)。结论 Caveolin-1敲除小鼠的体质量下降、繁殖性能下降。
|
| 关 键 词： | 小窝蛋白 基因敲除小鼠 体质量 繁殖性能 |
Effect of Caveolin-1 knockout on weight and reproductive performance before weaning in C57BL/6 mice |
| |
| YU Yue,YI Jian,CAI Guang-xian,LIU Bai-yan. Effect of Caveolin-1 knockout on weight and reproductive performance before weaning in C57BL/6 mice[J]. Journal of Traditional Chinese Medicine University of Hunan, 2011, 31(11): 7-8,15. DOI: 10.3969/j.issn.1674-070X.2011.11.002.007.02 |
| |
| Authors: | YU Yue YI Jian CAI Guang-xian LIU Bai-yan |
| |
| Affiliation: | (Key lab of Iinternal Medicine Constructed by Ministry-Province,TCM University of Hunan,Changsha,Hunan 410007,China) |
| |
| Abstract: | Objective evaluate the effects of Caveolin-1 knockout on weight and reproductive performance before weaning in C57BL/6 mice.Methods The growth curves,primiparous age,parity time interval,the average litter sizes and weaning survival were observed and analyzed respectively in caveolin-1 knockout mice and C57 mice homologous.Results The average body weight of C57BL/6 newborn mice were higher than that of Caveolin-1 knockout mice in 1st,7th and 14th days,but there were no significant differences(P>0.05);in 21st day,the difference was significant(P<0.05);the primiparous age,parity,litter size and the average interval between the two was no significant difference(P>0.05),but the survival rate of C57BL/6 mice was significantly higher than that of knockout mice(P<0.05).Conclusion Caveolin-1 knockout can slow the growth and decrease the reproductive ability of C57BL/6 mice. |
| |
| Keywords: | Caveolin-1 kncok-out mice growth curve body weight reproductive performance |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
