| FOLFOX4方案治疗中晚期肝癌的临床疗效 |
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| 引用本文： | 田浩,程朝辉,张瑞刚,庄广侠. FOLFOX4方案治疗中晚期肝癌的临床疗效[J]. 肿瘤基础与临床, 2011, 24(6): 495-496 |
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| 作者姓名： | 田浩 程朝辉 张瑞刚 庄广侠 |
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| 作者单位： | 新沂市人民医院肿瘤科,江苏新沂,221400 |
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| 摘 要： | 目的 探讨FOLFOX4方案治疗晚期肝癌的临床疗效及毒副反应.方法 17例晚期肝癌患者接受FOLFOX4方案(L-OHP 85mg/m2静脉滴注d1；CF 200 mg/m2静脉滴注d1.2；5-Fu 400 mg/m2静脉滴注d1,2；5-Fu 600 mg/m2持续静脉滴注d1,2；每3周重复)全身化疗,每例至少化...
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| 关 键 词： | 肝癌 化疗 FOLFOX4方案 |
The Clinical Effect of FOLFOX4 Regimen in the Treatment of Patients with Advanced Hepatocellular Cancer |
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| Tian Hao,Cheng Zhaohui,Zhang Ruigang,Zhuang Guangxia. The Clinical Effect of FOLFOX4 Regimen in the Treatment of Patients with Advanced Hepatocellular Cancer[J]. Journal of Basic and Clinical Oncology, 2011, 24(6): 495-496 |
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| Authors: | Tian Hao Cheng Zhaohui Zhang Ruigang Zhuang Guangxia |
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| Affiliation: | (Department of Oncology,the People’s Hospital of Xinyi,Xinyi 221400,China) |
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| Abstract: | Objective To observe the clinical effect and toxicities of FOLFOX4 regimen in the treatment of patients with advanced hepatocellular cancer. Methods Seventeen patients with advanced hepatocellular cancer were treated with FOLFOX4 regimen:L-OHP 85 mg/m2,ivgtt,d1;CF 200 mg/m2,ivgtt,d1,2;5-Fu 400 mg/m2,ivgtt,d1,2;and 5-Fu 600 mg/m2,CIA,d1,2.Three weeks were one cycle,and the effect and toxicities were evaluated after 2 cycles of chemotherapy. Results Among the 17 cases,no case was in CR,1 case was in PR,12 cases were in SD,4 cases were in PD.The total response rate was 5.9%.The clinical benefit rate was 76.5%.The major toxicities were gastrointestinal reaction and peripheral nerve toxicity. Conclusion FOLFOX4 regimen is a feasible systemic chemotherapy regimen for patients with advanced hepatocellular cancer,and it is effect and safe. |
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| Keywords: | hepatocellular cancer chemotherapy FOLFOX4 regimen |
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