生长相关蛋白在电针治疗大鼠脊髓损伤中的表达及意义 |
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引用本文: | 李振鹏,孔抗美,邹延澄,郭天明,林耿春. 生长相关蛋白在电针治疗大鼠脊髓损伤中的表达及意义[J]. 医学临床研究, 2011, 28(12): 2237-2239 |
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作者姓名: | 李振鹏 孔抗美 邹延澄 郭天明 林耿春 |
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作者单位: | 汕头大学医学院第二附属医院骨科,广东,汕头,515041 |
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基金项目: | 广东省卫生厅资助课题(项目编号:A2009445) |
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摘 要: | [目的]探讨生长相关蛋白(Gap-43)在电针治疗大鼠脊髓损伤(SCI)中的变化及意义.[方法]以2个月龄Wistar大鼠(96只)为受试对象,随机分为对照组(A组)、损伤组(B组)、治疗对照组(C组)和电流刺激治疗组(D组).B、C、D组于T9处行脊髓全横断,D组予电针治疗.用Western-blot测定各组损伤段脊...
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关 键 词: | 脊髓损伤/治疗 神经组织蛋白质类 电针 大鼠 |
Expression of Growth Associated Protein in Rats of Spinal Cord Injury Treated with Electro-acupuncture and Its Significance |
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Affiliation: | LI Zhen-peng,KONG Kang-mei,ZOU Yan-cheng ,et al ( Department of Orthopedics, Second Affiliated Hospital, Shantou University Medical College, Guangdong 515041, China ) |
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Abstract: | [Objective] To explore the change of growth associated protein(Gal〉43) in rats of spinal cord injury (SCI) treated with electro-acupuncture and its significance. [Methods] Totally 96 Wistar rats with 2-month age were selected as the subjects and randomly divided into the control group(group A), SCI group(group B), the sham-treatment group(group C) and the electro-acupuncture treatment group(group D). Group B, C and D underwent total-transect SCI at the vertebrae level of T9. Group D was treated with electro-acupuncture. Western-blot was used to examine the expression and change of Gap-3 in injured spinal cord at different time points. Hematoxylin-feosin and immunohistochemical staining methods were used to observe the morphology of injured spinal cord. [Results]A little expression of Gap-43 after SCI was found. After electro-acupuncture treatment, the expression of Gap-43 increased obviously. [Conclusion] Gap-43 is an important factor of nerve fiber regeneration after SCI. Electro-acupuncture can obviously promote the expression of Gap- 43 protein. |
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Keywords: | Spinal cord injuries/TH nerve tissue proteins electroacupuncture rats |
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