Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study |
| |
Authors: | Postuma R B Espay A J Zadikoff C Suchowersky O Martin W R W Lafontaine A-L Ranawaya R Camicioli R Lang A E |
| |
Institution: | Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada. ron.postuma@muhc.mcgill.ca |
| |
Abstract: | Elevated homocysteine is associated with increased risk of heart disease, stroke, and dementia. Therapy of Parkinson disease (PD) with levodopa elevates homocysteine. The authors conducted a 6-week, multicenter, randomized, double-blind, placebo-controlled trial to test whether folate 1 mg/vitamin B(12) 500 microg or entacapone reduced serum homocysteine in 35 levodopa-treated PD patients. Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine compared to placebo. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|