克罗米芬对卵巢储备功能减退患者进行促排卵治疗的有效性研究

目的:研究IVF/ISCI治疗中克罗米芬(CC)用于卵巢储备功能减退(DOR)患者促排卵治疗的效果。方法:回顾性分析年龄<35岁但基础FSH≥12 IU/L,或者年龄≥35岁患者的388个CC联合人绝经期促性腺素(hMG)的促排卵周期全胚行冻融胚胎移植(FET)的治疗结局,所有患者既往有≥1次促排卵治疗失败史。结果:年龄<35岁组,获卵数为4.5±3.1个,有效胚胎数为2.2±1.8个,优质胚胎数为1.6±1.5个,用药时间为8.8±2.0 d。在年龄≥35岁的患者中,获卵数为4.5±2.8个,有效胚胎数为2.2±1.8个,优质胚胎数为1.9±1.6个,用药时间为8.8±1.9 d。FET的临床妊娠率2个年龄组分别为37.8%和36.4%,组间无统计学差异(P>0.05)。结论:对于基础FSH水平高或者年龄≥35岁的DOR患者,CC联合hMG是一种有效的促排卵方案。

Effectiveness of Clomiphene Citrate on Diminished Ovarian Reserve Patients as An Ovarian Stimulation Protocol

Objective: To study the effectiveness of clomiphene citrate(CC) as an ovarian stimulation protocol in diminished ovarian reserve(DOR) women undergoing IVF/ICSI.Methods: The outcomes of 388 cycles who received CC plus human menopausal gonadotrophin(hMG) were retrospectively analyzed.The inclusion criteria was age <35 years old but basal FSH(bFSH)≥ 12 IU/L(group of age<35 years old),or age ≥ 35 years old(group of age ≥35 years old),all the patients had≥1 time failed ovary stimulation treatments.Results: In the group of age <35 years old,the number of retrieved eggs,embryos and good-quality embryos were 4.5 ± 3.1,2.2 ± 1.8,1.6 ± 1.5,respectively.The treated days was 8.8 ± 2.0 d,the clinical pregnancy rate of FET was 37.8%.In the group of age ≥ 35 years old,the number of retrieved eggs,embryos and good-quality embryos were 4.5 ± 2.8,2.2 ± 1.8,1.9 ± 1.6,respectively.The duration of treatment was 8.8 ± 1.9 d,the clinical pregnancy rate of FET was 36.4%.Conclusion: The CC combined with hMG as an ovarian stimulation protocol has been proven to be effective in DOR patients undergoing IVF/ICSI.