中西医结合治疗肺癌患者的白细胞介素—2系统,T细胞及 …

目的：观察中西医结合治疗现癌患者的白细胞介素－２（ＩＬ－２）系统、Ｔ细胞及红细胞免疫系统动态改变与评估。方法：随机将肺癌患者分为两组：Ⅰ组（化疗加中药）２５例，Ⅱ组（化疗）２３例。动态观察治疗前后免疫指标及生存质量、临床证候与瘤体改变。且以健康人为对照。结果：（１）肺癌患者轿清ＩＬ－２与可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）分别显著低于与高于对照组。治疗后上述指标分别显著回升和下降。尤以Ⅰ组改善

DynamicObservation and Clinical Significance of Integrated Traditional Chinese and WesternMedicine on Interleukin-2 System, T Cell and Erythrocyte Immune System in Patients of LungCancer

OBJECTIVE: To study the dynamic changes and its clinical significance of integrated traditional Chinese and western medicine (TCM-WM) on IL-2 system, T cell and erythrocyte immune system in patients of lung cancer. METHODS: Forty-eight cases with lung cancer were randomly divided into two groups: TCM-WM group (group I) and the chemotherapy group (group II); and 20 healthy subjects were simultaneously compared. The relevant immune indices, clinical symptoms and signs, changes of solid tumor and living quality were dynamically observed. RESULTS: (1) The serum IL-2 level of lung cancer patients were significantly lower, while sIL-2R level higher than that of the healthy subjects. And they were raised and lowered respectively after treatment, especially in the group I, but different from the control group yet. And there were highly negative correlation between IL-2 and sIL-2R levels. (2) The percentage of CD3, CD4 and the ratio CD4/CD8 were decreased markedly in both groups, except CD8 which was increased markedly. And the percentage of RBC-C3b RR was obviously lower, while that of RBC-ICR was obviously higher. But the above-mentioned indices could be improved after treatment, especially in the group I, and there were highly positive correlation between CD4/CD8 ratio and RBC-C3bRR. (3) After treatment, all above-mentioned indices were changed significantly to their corresponding opposites. However, in regard to the degree of improvement, the patients of group I were in a better position than those of group II. At the same time, improvement of their clinical symptoms and signs, change of solid tumor and living quality also showed advantageous. CONCLUSION: The therapeutic superiority of TCM-WM on lung cancer may be related with the modulation on immune function. Thus we can say that the effect of TCM-WM is better than that of chemotherapy alone.