SF-36量表在慢性乙型肝炎患者生存质量中的应用研究

目的测量并评价慢性乙型肝炎患者的生存质量（QOL）。方法采用SF-36量表,对66例慢性乙型肝炎患者和60例正常对照进行QOL测量与评价,并对QOL的影响因素进行单因素分析和多因素逐步回归分析。结果慢性乙型肝炎患者的平均SF-36总评分及生理机能、角色生理状况、心理健康状况、角色心理状况、社会机能、活力、躯体疼痛和主观健康状况的平均评分分别为56±17、65±24、21±30、62±18、28±34、55±28、57±2、68±25和52±16,与对照组相比,差异有统计学意义（P均〈0.001）。慢性乙型肝炎患者的平均生存质量指数评分（7.2±2.2）与对照组相比,差异有统计学意义（P〈0.01）。慢性乙型肝炎患者SF-36总评分及其8个分项目相互之间相关系数均具有统计学意义（P〈0.01）。SF-36总评分与生存质量指数评分呈极显著性正相关（r=0.7841,P均〈0.01） 影响慢性乙型肝炎患者QOL的主要因素是临床分型、乏力、腹水、黄疸、脾肿大、血清ALT与总胆红素升高、血浆白蛋白或（A/G）降低以及HbeAg、HBV-DNA持续阳性等。结论SF-36适用于我国慢性乙型肝炎患者QOL的测量。

Research of SF-36 in Quality of Life in Patient with Chronic Hepatitis B

Objective To measure and assess the quality of life（QOL） of patients with chronic hepatitis B（CHB）.Methods QOL of 66 patients with CHB and 60 healthy controls were evaluated by Mos SF-36,and QOL scores,single and multiple stepwise regression analysis were made to assess the factors affecting QOL.Results The average total score of SF-36,individual physiologic function,physical and mental health,emotional and social status,vitality,trunkal aching and general health were 56±17,65±24,21±30,62±18,28±34,55±28,57±2,68±25 and 52±16,respectively in the CHB group.There were statistically significant differences between CHB group and the control group（P values all0.01）.The average of QLI was 7.2±2.2 in the CHB group,and significant differences were also found as compared with that of the controls（P0.01）.The total score of SF-36 and scoring of QLI were positively correlative（r=0.7841,P0.01）.The factors affecting the scores of SF-36 of these patients were mainly：clinical pattern,weakness,ascites,jaundice,splenomegaly,elevation of serum ALT and total bilirubin,decrement of plasma and ALB,continued positivty of HbeAg and HBV DNA etc.Conclusion The SF-36 score was eligible for assesement of QOL of patients with CHB.