| 糖耐康对糖尿病KKAy小鼠IL-6及TNF-α的影响 |
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| 引用本文： | 贾淑明,文萍,刘铜华.糖耐康对糖尿病KKAy小鼠IL-6及TNF-α的影响[J].国际中医中药杂志,2008,30(3). |
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| 作者姓名： | 贾淑明 文萍 刘铜华 |
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| 作者单位： | 北京中医药大学,北京,100029 |
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| 基金项目： | 北京市科技研发攻关项目 |
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| 摘 要： | 目的 观察中药糖耐康对2型糖尿病KKAy小鼠血清及脂肪组织IL-6和TNF-α的影响.方法 以发病周龄的KKAy小鼠为研究对象,加高脂饲料制备2型糖尿病模型,经灌胃精耐康8周后,血糖仪试纸法测空腹血糖(FBG),ELISA法测血清及脂肪组织IL-6和TNF-α的含量.结果 糖耐康能很好地降低血清及脂肪的IL-6和TNF-α水平(P均＜0.05),高低剂量疗效相近.结论 糖耐康可降低KKAy小鼠血清和脂肪细胞的IL-6和TNF-α水平;有助于降低血糖水平.
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| 关 键 词： | 糖尿病 糖耐康 TNF-α |
The Effects of Tangnaikang on IL-6 and TNF-α in Serum and Adipocytes of Diabetic KKAy Mice |
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| JIA Shu-ming,WEN Ping,Liu Tong-hua.The Effects of Tangnaikang on IL-6 and TNF-α in Serum and Adipocytes of Diabetic KKAy Mice[J].International Journal of Traditional Chinese Medicine,2008,30(3). |
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| Authors: | JIA Shu-ming WEN Ping Liu Tong-hua |
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| Abstract: | Objective To observe the effects of Tangnaikang on interleukin 6 (IL-6) and minor necrosis factor-α(TNF-α) levels of Diabetic KKAy mice. Methods After diabetic KKAy mice were treated with Tangnaikang for 8 weeks,FBG was determined by glucose test-paper, IL-6 and TNF-αconcentratious in serum and adipocytes were determined by ELISA. Results IL-6 and TNF-α levels were reduced in serum and adipocytes of KKAy mice. Conclusion Tangnaikang can significantly reduce the levels of IL-6 and TNF-α in Diabetic KKAy mice, and the reduction of them can help to decrease FBG level. |
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| Keywords: | IL-6 |
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