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门冬氨酸钾镁联合氯化钾与硫酸镁联合氯化钾治疗心力衰竭的比较
引用本文:刘圳奋,尹虹,汪振江,崔静玉.门冬氨酸钾镁联合氯化钾与硫酸镁联合氯化钾治疗心力衰竭的比较[J].中国新药与临床杂志,1999,18(2).
作者姓名:刘圳奋  尹虹  汪振江  崔静玉
作者单位:兰州市第一人民医院内科,甘肃兰州730050
摘    要:目的:比较门冬氨酸钾镁联合氯化钾(门冬联用组)与硫酸镁联合氯化钾(硫酸镁联用组)在治疗充血性心力衰竭(CHF)中的疗效。方法:将270例CHF病人分为2组。门冬联用组99例在常规治疗基础上加用门冬氨酸钾镁40~60mL联合10%氯化钾10mL治疗;硫酸镁联用组171例加用25%硫酸镁5~10mL联合10%氯化钾10~15mL治疗;2组药物均分别溶于5%葡萄糖注射液500mL中静脉滴注,qd,疗程均为10d。结果:门冬联用组对难治性CHF的疗效优于硫酸镁联用组(P<0.05);前者抗心律失常疗效优于后者,且无明显不良反应,而后者因Mg2+相对高浓度的扩血管作用,在CHF血压偏低状态下其应用受到限制。结论:治疗CHF门冬联用氯化钾优于硫酸镁联用氯化钾。

关 键 词:钾镁天冬氨酸盐  氯化钾  硫酸镁  充血性心力衰竭  心律失常

Potassium magnesium aspartate plus potassium chloride vs magnesium sulfate plus potassium chloride in treatment of heart failure
LIU Zhen-Fen,YIN Hong,WANG Zhen-Jiang,CUI Jing-Yu.Potassium magnesium aspartate plus potassium chloride vs magnesium sulfate plus potassium chloride in treatment of heart failure[J].Chinese Journal of New Drugs and Clinical Remedies,1999,18(2).
Authors:LIU Zhen-Fen  YIN Hong  WANG Zhen-Jiang  CUI Jing-Yu
Abstract:AIM: To compare the clinical efficacies between potassium magnesium aspartate plus potassium chloride and magnesium sulfate plus potassium chloride in the treatment of congestive heart failure (CHF). METHODS: Two hundred and seventy patients with CHF were divided into 2 groups, on the basis of conventional therapy. The first group (M 68, F 31; age 58 a±s 8 a) was treated with addition of potassium magnesium aspartate 40_60 mL plus 10% potassium chloride 10 mL; and second group (M 126, F 45; age 53 a±8 a) was treated with the addition of 25% magnesium sulfate 5_10 mL plus 10% potassium chloride 10_15 mL, both in 5% glucose injection 500 mL, iv, drip, qd×10 d. RESULTS: The first group were better than the second group in the treatment of refractory heart failure (P<0.05) and cardiac arrhythmias. Adverse reactions were not found in the first group. In the second group, when the patients were in the state of low_blood pressure, the medicines were confined because of the higher concentration of magnesium. CONCLUSION: Potassium magnesium aspartate plus potassium chloride were better than magnesium sulfate plus potassium chloride in the treatment of CHF.
Keywords:potassium magnesium aspartate  potassium chloride  magnesium sulfate  congestive heart failure  arrhythmia
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