紫杉醇加5-氟脲嘧啶持续滴注治疗晚期鼻咽癌

目的：观察紫杉醇（Paclitaxel)，醛氢叶酸（Leucovorin),5-氟脲嘧啶（5－Fluorouraicl)持续滴注治疗晚期鼻咽癌的疗效及其不良好反应。方法：经病理组织学诊断的鼻咽癌患者20例（研究组），紫杉醇150mg/m^2，静脉滴注3h，第1天，醛氢叶酸200mg/m^2，静脉滴注2h，随后5－Fu375mg/m^2静脉推注10min再接5－Fu3.0g/m^2用输液泵连续滴注48h,以上治疗21天为1个周期，所有患者至少接受2个疗程治疗，结果：20例均可评价疗效，完全缓解（CR）3例（15．0％），部分缓解（PR）10例（50．0％），4例患者稳定（20．0％），主要不良反应为骨髓抑制，恶心、呕吐、肌肉疼痛和关节痛，黏膜炎等，经常规预防用药后，未出现严重的过敏反应，无治疗相关性死亡者，结论：该研究表明，紫杉醇加醛氢叶酸和5－Fu持续滴注治疗晚期鼻咽癌患者，缓解率较高，毒性相对较弱，值得进一步临床研究。

Paclitaxel Combined with 5-Fluorouracil Continuous Infusion for Treatment of Advanced Nasopharyngeal Carcinoma

Objective To evaluate the efficacy and toxicity of Paclitaxel combined with Leucovorin/5-Fluorouracil continuous infusion in the patients with advanced nasopharyngeal carcinoma.Methods The patients with a histologic diagnosis of NPC were eligible.The chemotherapy regimen was comprised of paclitaxel 150 mg/m 2 infusion for 3 hours,leucovorin 200 mg/m 2 infusion for 2 hours followed by 10 minute intravenous bolus of 5-Fu 375 mg/m 2,then 48 hours infusion of 5-Fu 3.0 g/m 2 with an ambulatory pump,repeated every 3 weeks.All patients were received at least two cycles of the treatment.Results Twenty patients were enrolled into this study.After two cycles of chemotherapy,3 obtained complete remission(CR)(15.0%),10 obtained partial remission(PR)(50.0%),4 had stable disease(SD)(20.0%).The major toxicity included neutropenia,nausea vomiting arthralgia,myalgia and mucositis.All patients were pretreated with dexamethasone,diphenhydramine and ranitidine.No severe hypersensitivity reaction was observed,no treatment-related death occurred.Conclusion The study indicated that paclitaxel combined with leucovorin/5-Fluorouracil continuous infusion for treatment of advanced NPC had moderate activity and comparatively mild toxicity.Further clinical investigation should be warranted.