| 赖氨酸羟化酶的研究进展 |
| |
| 引用本文： | 谭彬,罗忠金,张吉翔. 赖氨酸羟化酶的研究进展[J]. 医学分子生物学杂志, 2005, 2(3): 220-223 |
| |
| 作者姓名： | 谭彬 罗忠金 张吉翔 |
| |
| 作者单位： | 江西省分子医学重点实验室,江西医学院第二附属医院消化科,南昌市,330006;江西省分子医学重点实验室,江西医学院第二附属医院消化科,南昌市,330006;江西省分子医学重点实验室,江西医学院第二附属医院消化科,南昌市,330006 |
| |
| 基金项目： | 国家自然科学基金(No.30160032)~~ |
| |
| 摘 要： | 赖氨酸羟化酶(lysyl hydroxylase,LH)是催化胶原蛋白和另外15种以上蛋白质中赖氨酸羟化的酶类,它在一些生理和病理过程中扮演着重要的角色。LH有多种同工酶,其活性需依赖一些辅基的存在,同时也受到一些物质的抑制。研究发现一些组织纤维化性疾病和遗传性疾病与LH有很大的关系。近年来,随着对该酶研究的深入,有望找到这些疾病治疗的新靶点。
|
| 关 键 词： | 赖氨酸羟化酶 纤维化 Ⅵ型Ehlers-Demlos综合征 Bruck综合征 |
| 修稿时间： | 2004-10-25 |
Advances in the Study of Lysyl Hydroxylase |
| |
| Tan Bin,LUO Zhongjin,Zhang Jixiang. Advances in the Study of Lysyl Hydroxylase[J]. Journal of Medical Molecular Biology, 2005, 2(3): 220-223 |
| |
| Authors: | Tan Bin LUO Zhongjin Zhang Jixiang |
| |
| Affiliation: | TAN Bin,LUO Zhongjin,ZHANG Jixiang Jiangxi Provincial Key Laboratory of Molecular Medicine,Department of Digestion,the Second Affiliated Hospital,Jiangxi Medical College,Nanchang,330006,China |
| |
| Abstract: | Lysyl hydroxylase (LH) catalyzes the hydroxylation of lysine in collagens and more than 15 other proteins and it plays an important role in the physiological and pathological processes in the human beings. LH has a variety of isoenzymes, the functions of which depend on some cosubstrates and can be inhibited by some substances. Previous researches have shown that it is related with some fibrotic and inherited diseases and futher study of the enzyme may help us find new targets for the treatment of the diseases. |
| |
| Keywords: | |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
