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uPA is upregulated by high dose celecoxib in women at increased risk of developing breast cancer |
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| Authors: | Wenyi Qin Weizhu Zhu John E Hewett George Rottinghaus Yin-Chieh Chen John T Flynn Beth Kliethermes Ferdinando Mannello Edward R Sauter |
| Affiliation: | (1) Department of Surgery, University of North Dakota, Grand Forks, ND, USA;(2) Departments of Biostatistics, University of Missouri, Columbia, MO, USA;(3) Veterinary Medical Diagnostics, University of Missouri, Columbia, MO, USA;(4) Institute of Histology and Laboratory Analysis, Thomas Jefferson University, Philadelphia, PA, USA;(5) Department of Physiology, Thomas Jefferson University, Philadelphia, PA, USA;(6) University "Carlo Bo", 61029 Urbino, Italy |
| Abstract: | BackgroundWhile increased urokinase-type plasminogen activator (uPA) expression in breast cancer tissue is directly associated with poor prognosis, recent evidence suggests that uPA overexpression may suppress tumor growth and prolong survival. Celecoxib has been shown to have antiangiogenic and antiproliferative properties. We sought to determine if uPA, PA inhibitor (PAI)-1 and prostaglandin (PG)E2 expression in nipple aspirate fluid (NAF) and uPA and PGE2 expression in plasma were altered by celecoxib dose and concentration in women at increased breast cancer risk. |
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