| 姜黄素对NB4细胞的诱导凋亡机制 |
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| 引用本文： | 刘加军,伍新尧,王江峰,潘祥林,吕德坚. 姜黄素对NB4细胞的诱导凋亡机制[J]. 肿瘤研究与临床, 2003, 15(6): 371-373 |
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| 作者姓名： | 刘加军 伍新尧 王江峰 潘祥林 吕德坚 |
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| 作者单位： | 1. 中山大学中山医学院,广东,广州,510080
2. 山东大学第二医院,山东,济南,250033 |
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| 基金项目： | 广东省自然科学基金项目资助 (0 0 13 86) |
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| 摘 要： | 目的：研究姜黄素对急性白血病NB4细胞的诱导凋亡作用，并对其作用机制进行探讨。方法：以不同浓度的姜黄素作用于体外培养的NB4细胞、检测细胞生长抑制率，观察细胞凋亡时的形态学变化，对细胞凋亡前后的Caspase3活性进行检测。结果：姜黄索可显著地提高NB4细胞Caspase3活性，抑制细胞的生长，诱导细胞发生凋亡。并呈现出明显的量-效与时-效关系。结论：姜黄素能诱导NB4细胞调亡，升高Caspase3活性是其重要作用机制之一。
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| 关 键 词： | 姜黄素 Caspases3 细胞凋亡 |
| 文章编号： | 1006-9801(2003)06-0371-03 |
| 修稿时间： | 2003-11-01 |
MECHANISM OF CURCUMIN INDUCED APOPTOSIS ON NB4 CELLS |
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| LIU Jia-jun,WU Xin-yao,WANG Jiang-feng,et al.. MECHANISM OF CURCUMIN INDUCED APOPTOSIS ON NB4 CELLS[J]. Cancer Research and Clinic, 2003, 15(6): 371-373 |
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| Authors: | LIU Jia-jun WU Xin-yao WANG Jiang-feng et al. |
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| Affiliation: | LIU Jia-jun,WU Xin-yao,WANG Jiang-feng,et al.Medical College of Sun Yat-Sen University |
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| Abstract: | Objective:To explore the mechanisms of curcumin induced apoptosis on NB_4(Human acute promylocytic leukeamia cell line) cells.Methods:The variation of both morphology and inhibitory rate of NB_4 cells were observed in culture medium with various concentrations of Curcumin at different time in vitro. The activity of Caspase3 was detected before and after apoptosis occurred.Results:Curcumin could increase the activity of Caspase3, inhibit the growth and cause apoptosis on NB_4 cells significantly. The variations were both in time and dose-dependent manner.Conclusion:Curcumin can inhibit the growth of NB_4 cells and induce apoptosis,increasing the activity of Caspase3 may be one of the most important mechamisms. |
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| Keywords: | Curcumin Caspase3 Apoptosis |
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