脑内肥大细胞在多发性硬化和Wernicke脑病中的作用

肥大细胞作为机体固有免疫系统的一种多功能效应细胞，它在免疫反应等病理和生理过程中的作用已研究得较深入，但是，对于它在中枢神经系统疾病中的作用了解得仍较少。近年研究发现，肥大细胞是多发性硬化以及Wernicke脑病发生、发展过程中的重要因素。多发性硬化是一种以中枢神经系统炎性脱髓鞘为特征的慢性疾病，而Wernicke脑病是与物质代谢紊乱有关的疾病。肥大细胞可能通过其释放的介质，促进神经损伤，加快病程并加重病情。深入研究肥大细胞与这两种疾病的内在关系，并进一步研发针对疾病过程中肥大细胞的药物，将为它们的诊治提供新的方向。

Role of brain mast cell in multiple sclerosis and Wernicke''''s encephalopathy

Mast cell which is considered to participate in immune response has long been studied.However its true role in center nervous system is still unknown.Recently,mast cell has been found to play an important function during the process of multiple sclerosis and Wernicke's encephalopathy in the brain.Multiple sclerosis is an inflammatory demyelinating disease,and Wernicke's encephalopathy is caused by deficiency of thiamine.Mast cell deteriorates the neuronal damage and the course of diseases by their mediators.Such studies may supply new idea on the therapy of these diseases.