Comparison of the Effects of Single Morning and Single Bedtime Doses of Famotidine on Intragastric Acidity in Patients with Gastric Ulcer |
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| Authors: | Masahide Arita M.D. Mitsuo Okada M.D. Akira Motomura M.D. Toshiyuki Matsui M.D. Kiyomi Hosiko M.D. Tsuneyoshi Yao M.D. |
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| Affiliation: | Department of Gastroenterology, Fukuoka University Chikushi Hospital, and First Department of Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan |
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| Abstract: | The effects of single morning and single bedtime doses of famotidine on intragastric acidity were studied by 24-b intragastric pH monitoring in 16 patients with gastric ulcer. The patients were randomly allocated to tbe following regimen: one group (n = 8) received 40 mg famotidine at 8:30 AM and anotber group (n = 8) received tbo same dose at 10 PM. Tbe morning group showed significant inbibition of gastric acidity during the 24-b and daytime measurements, compared to those of the bedtime group (p < 0.05 in 24 h, p < 0.01 in daytime). Conversely, tbe bedtime group sbowed a sig-nificant inbibition of gastric acidity during tbe nocturnal period compared to tbe morning group (p < 0.01). These results indicate that the relative importance of suppression of gastric acidity on tbe gastric ulcer heal-ing process sbould be evaluated in a clinical trial. |
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