重庆地区病毒性肝炎患者血清病毒标志分析

目的 探讨重庆地区病毒性肝炎患者的病原感染状况。方法 采用EIA法对295例各型肝炎患者血清进行了甲～庚型肝炎病毒12种血清标志的检测。结果 甲～庚型肝炎病毒血清标志阳性共234例(79.32％)。其中抗-HAV IgM阳性71例(24.07％),HBVM58.98％(174例),抗-HCV8.13％(24例),HDVM29.15％(86例),抗-HEV和抗-HGV分别为22.37％(66例)和16.95％(50例)。在234例甲～庚型肝炎病毒感染者中,仅71例(30.34％)检出一种肝炎病毒血清标志,其余均为重叠感染。两种肝炎病毒血清标志阳性者85例(36.32％),三种重叠感染者50例(21.37％),四种阳性的21例(8.97％),还有两例可同时检出五种肝炎病毒标志。结论 重庆地区病毒性肝炎患者中以HBV感染最多,HCV最少,HDV占相当比例。但仍可能存在甲～庚型以外的其他肝炎病毒感染者。几种肝炎病毒重叠感染可能是造成肝炎慢性化和重型化的重要因素之一。

SEROLOGICAL INVESTIGATION OF HEPATITIS A TO G VIRUSES IN PATIENTS WITH HEPATITIS IN CHONGQING AREA

Objective To investigate serologically hepatitis A-G virus infections in patients with hepatitis in Chongqing area. Methods Serum markers of hepatitis A-G viruses were determined by EIA method. Results 234 out of 295 cases (79. 32 % ) were serum markers positive. The positive rate of anti HAV-IgM was 24.07% (71/295), HBVM58.98% (174/295) ,anti HCV 8.13% (24/295) ,HDVM 29.15% (86/295) ,anti HEV 22.37% (66/295)and anti HGV 16. 95% (50/295). In 234 individuals with hepatitis, 71 (30. 34% ) patients were infected with only one hepatitis virus,while the rest(67. 5%) were with coinfection. Positive serum markers of two hepatitis viruses were found in 85 cases(36. 32% ) ,of three hepatitis viruses in 50(21.37% ) ,of four hepatitis viruses in 21(8. 97% )and of five in 2 cases. Conclusion In patients with hepatitis in Chongqing area,HBV was the mast common infection a-gent, while HCV infection was relatively rare. Coinfection of several hepatitis viruses might be the important cause resulting in chronic and severe hepatitis.