Hepatocyte growth factor (HGF) in patients with acute brucellosis |
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Authors: | Ozden Mehmet Kalkan Ahmet Demirdag Kutbettin Kilic S Sirri Denk Affan Yuce Pinar |
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Affiliation: | Department of Immunology, Faculty of Medicine, University of Firat, TR-23119, Elazig, Turkey. ozdenm44@hotmail.com |
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Abstract: | In this prospective study, we investigated the serum levels of hepatocyte growth factor (HGF) and C-reactive protein (CRP) before and after the treatment of patients with acute brucellosis. The study comprised 58 patients with acute brucellosis and 30 healthy volunteers. Pre-treatment serum HGF levels of 58 patients with acute brucellosis (1548.6 +/- 220.1) were significantly higher than levels of the control group (401.4 +/- 69.7) (p < 0.001). Serum levels of HGF and CRP significantly decreased at the end of the treatment period (p < 0.001). Post treatment, levels did not differ from those of the control group (p > 0.05). Serum HGF levels of patients with acute brucellosis correlated to CRP and ALT levels (r: 0.922, 0.752; p < 0.001, respectively). Our findings suggest that serum HGF levels may be used as a supplementary marker to evaluate the effectiveness of the treatment in patients with acute brucellosis. |
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