喉癌P53、nm23蛋白和VEGF表达的临床病理意义

目的:探讨P53、nm23基因和血管内皮生长因(vascular endothelial growth facor)在喉癌中的的表达及其与喉癌生物学行为的关系.方法:通过免疫组化SP法对42例喉癌标本中P53、nm23蛋白、VEGF进行了检测.结果:喉癌中P53、nm23蛋白及VEGF的阳性表达率分别为47.62%、57.10%和71.42%.P53基因表达和VEGF呈正相关(P<0.05),在有淋巴结转移的肿瘤中P53、VEGF阳性表达率明显高于非转移组(P<0.05).nm23基因表达和VEGF无相关性,nm23基因阴性和VEGF阳性表达的病人,淋巴结转移多见.P53基因阳性表达和nm23基因阴性表达的喉癌易发生颈淋巴结转移.结论:P53、nm23蛋白和VEGF与喉癌转移及预后密切相关;可能作为判断喉癌生物学行为及预后的重要指标.

EXPRESSIONS OF P53, NM23 PROTEIN AND VEGF IN LARYNGEAL CANCER AND ITS CLINIC OPATHOLOGIC SIGNIFICANCE

Objective: To investigate the expression of P53, nm23 proteins and VEGF in laryngo carcinoma and their correlation with the biological behavior of laryngo carcinoma. Methods:42 specimens of laryngo carcinomas were examined by immunohistochemical stainning for P53 protein, nm23 protein, and VEGF antibody. Results:Positive rates of P53 protein, nm23 protein and VEGF were 47.62% ,57.10% and71.42% respectively. There was a positive correlation between the expression of P53 and VEGF expression. The P53-or VEGF-protein positive rates of tumors was significantly higher in patients with cervical lymph node metastasis than without metastasis.No correlation was found between the nm23 and VEGF staining. The cervical lymph node metastasis in VEGF-positive and nm23-negative tumors was significantly high .The laryngeal carcinomas of p53 positive and nm23 negative inpatients with cervical lymph node metastasis were more than that in patients without metastasis.Conclusion:P53, nm23 and VEGF is closely related to metastasis and prognosis of laryngo carcinoma;and can be regarden as the biological behavior and progrosis markers for laryngo carcinoma.