| 血小板/内皮细胞粘附分子在急性排斥反应时表达的研究 |
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| 引用本文： | 郭颖,郭琳琅.血小板/内皮细胞粘附分子在急性排斥反应时表达的研究[J].临床泌尿外科杂志,1998(3). |
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| 作者姓名： | 郭颖 郭琳琅 |
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| 作者单位： | 第一军医大学附属珠江医院血液净化肾移植科!广州510282(郭颖)，第一军医大学附属珠江医院病理科(郭琳琅) |
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| 摘 要： | 应用免疫级化SP法和计算机图像分析系统观察分析18例急性排斥反应时移植肾活检标本中血小板／内皮细胞粘附分子（PECAM－1，CD31）的表达。结果显示急性排斥反应时肾小球毛细血管内皮细胞中PECAM－1阳性反应强度较正常明显减低或由阳性转为阴性，而在肾小管上皮中表达增强；PECAM－1与HLA－DR抗原在肾小球和肾小管中的表达呈平行关系。提示细胞粘附分子PECAM－1对移植肾急性排斥反应有一定诊断意义。
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| 关 键 词： | 细胞粘附分子 肾移植 排斥反应 |
A study on cell adhesion molecule PECAM-1 in renal tissue during acute allograft rejection |
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| Guo Ying, Guo Linlang.A study on cell adhesion molecule PECAM-1 in renal tissue during acute allograft rejection[J].Journal of Clinical Urology,1998(3). |
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| Authors: | Guo Ying Guo Linlang |
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| Abstract: | The changes of cell adhesion molecule PECAM-1 in 18 cases during acute allograft rejection were studied by immunohistochemisty technique (SP method) and computer imaging anal ysis system. The results showed that PECAM-1 expression decreased in glomerular capillary en dothelial cells but increased in tuberular cells during acute allograft rejection. There was a signifi cant relationship between PECAM-1 and HLA-DR antigen. Our data suggested that changes of PECAM-1 might have some values in judging the acute allograft rejection. |
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| Keywords: | Cell adhesion molecule Allograft Rejection |
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