超敏C反应蛋白与2型糖尿病大血管病变的关系

目的探讨超敏C反应蛋白（hsCRP）与2型糖尿病大血管病变的关系。方法收集122例2型糖尿病合并大血管病变患者（大血管病变组）、60例无大血管病变的2型糖尿病患者（2型糖尿病组）、35例健康人（对照组）的临床资料。比较3组hsCRP水平的差异,分析hsCRP的相关因素。采用Logistic回归分析探讨2型糖尿病患者大血管病变的相关因素。结果大血管病变组hsCRP水平高于2型糖尿病组及对照组（P〈0.05或P〈0.01）;2型糖尿病组hsCRP水平高于对照组（P〈0.05）。相关分析表明,hsCRP与糖尿病病程、高血压、体质量指数（BMI）、糖化血红蛋白（HbA1c）、空腹血糖（FPG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）呈正相关（P〈0.05或P〈0.01）,与高密度脂蛋白胆固醇（HDL-C）呈负相关（P〈0.05）。Logistic回归分析显示2型糖尿病大血管病变与HbA1c、hsCRP、糖尿病病程有关。结论 hsCRP是2型糖尿病大血管病变的重要相关因素,hsCRP可能是2型糖尿病大血管病变的独立预测因子,慢性炎症反应可能参与了2型糖尿病大血管病变的发生发展。

Association Between High Sensitivity C-reactive Protein and the Macrovascular Complications in type 2 Diabetic Patients

Objective To explore the association between high sensitivity C-reactive protein（ hsCRP） and the macrovascular complications in type 2 diabetic patients. Methods 122 type 2 diabetes patients with macrovascular complications（ macrovascular complication group） and 60 type 2 diabetes patients without macrovascular complications（ type 2diabetes group） and 35 cases of normal controls（ control group） were recruited into our study. The hsCRP levels were compared within the three groups and the relevant factors of hsCRP were analysed. Logistic regression analysis was used to study the relevant factors of the macrovascular complications in type 2 diabetic patients. Results The hsCRP levels of macrovascular complication group were higher than those of type 2 diabetes group and control group（ P〈 0.05 or P〈 0.01）. The hsCRP levels of type 2 diabetes group were higher than those of control group（ P〈 0.05）. As to hsCRP level,it was negatively correlated with HDL-C（ P〈 0.05）,and positively correlated with diabetic duration,hypertension,BMI,HbA1c,FPG,TC,LDL-C（ P〈 0.05 or P〈 0.01）. Logistic regression showed that HbA1c、hsCRP、diabetic duration were significantly correlated with macrovascular complications in type 2 diabetic patients. Conclusions The hsCRP is important relevant factor of macrovascular complications in type 2 diabetic patients,suggesting that hsCRP seems to be a risk factor of macrovascular complications in type 2 diabetic patients. Inflammation seems to play a role in the initiation and progression of type 2 diabetic macrovascular complication.