血必净注射液结合西医常规疗法治疗高血压肾损害临床研究 |
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引用本文: | 张亚静,张辉凯.血必净注射液结合西医常规疗法治疗高血压肾损害临床研究[J].国际中医中药杂志,2016(9):779-782. |
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作者姓名: | 张亚静 张辉凯 |
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作者单位: | 1. 300193天津中医药大学第一附属医院心血管科;2. 450000河南省郑州市中医院肝病科 |
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摘 要: | 目的:评价血必净注射液结合西医常规疗法治疗高血压肾损害的疗效。方法将符合入选标准的114例高血压肾损害患者按随机数字表法分为2组,每组57例。对照组常规口服马来酸依那普利片+氨氯地平阿托伐他汀钙片,治疗组在对照组基础上加用血必净注射液。2组均治疗6个月。分别于治疗前后监测患者24 h动态血压(ambulatory blood pressure monitoring, ABPM)、24 h平均收缩压(systolic blood pressure, SBP)与舒张压(diastolic blood pressure,DBP),以及SBP与DBP变异性;采用免疫比浊法检测尿微量白蛋白(urinary albumin, mAlb)、尿β2-微球蛋白(β2-microglobulin,β2-MG)、尿微量白蛋白与肌酐比值(albumin to creatinine ratio,ACR);采用酶联免疫吸附实验检测血浆D-二聚体、IL-6、TNF-α和血浆纤维蛋白原(Human fibrinogen,FIB)。结果治疗后2个月、6个月,治疗组24 h平均收缩压、24 h平均舒张压、收缩压变异性、舒张压变异性均低于对照组(治疗后2个月t值分别为5.256、5.595、5.265、2.564,治疗后6个月t值分别为6.251、5.267、4.466、5.264,P值均<0.05);尿mAlb、尿β2-MG、ACR均低于对照组(治疗后2个月t值分别为5.566、5.282、2.862,治疗后6个月t值分别为5.263、6.565、3.642,P值均<0.05);血浆D-二聚体、IL-6、TNF-α和FIB水平低于对照组(治疗后2个月t值分别为3.565、5.652、3.985、5.251,治疗后6个月t值分别为5.268、4.836、3.622、4.265,P值均<0.05)。结论血必净注射液结合西医常规疗法可减轻高血压肾损害患者的肾损伤,使血压维持在相对稳定状态。
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关 键 词: | 高血压 肾性 肾损伤 血必净注射液 中西医结合疗法 |
The clinical study ofXuebijing injection combined with routine western medicine therapy on the treatment of hypertensive renal damage |
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Abstract: | Objective To evaluate the curative effect ofXuebijing injection combined with routine western medicine therapy in the treatment of hypertensive renal damage.Methods A total of 114 patients with hypertension were randomly divided into 2 groups according to the random number table method, 57 patients in each group. The control group was given conventional treatment (maleic acid enalapril and amlodipine and atorvastatin cutting atorvastatin calcium), and the treatment group were givenXuebijing injection based on the conventional treatment. The two groups were treated for 6 months. The changes of blood pressure, renal function and serum inflammatory cytokine levels were evaluated.Results After treatment, the mean value of 24 h systolic blood pressure, mean value of 24 h diastolic blood pressure, systolic blood pressure variability and diastolic blood pressure variability in the treatment group were significantly lower than those in the control group (2 months after treatment:t values were 5.256, 5.595, 5.265, 2.564,P<0.05; 6 months after treatment:t values were 6.251, 5.267, 4.466, 5.264,P<0.05); the urinary mAlb, beta 2-MG, and urine albumin to creatinine ratio in the treatment group were significantly lower than those in the control group (2 months after treatment:t value were 5.566, 5.282, 2.862,P<0.05; 6 months after treatment:t value were 5.263, 6.565, 3.642,P<0.05);two plasma D-dimer, IL-6, TNF-α and fibrinogen levels in the treatment group were significantly lower than those in the control group (2 months after treatment:t value were 3.565, 5.652, 3.985, 5.251,P<0.05; 6 months after treatment:t value were 5.268, 4.836, 3.622, 4.265,P<0.05).ConclusionsXuebijing injection combined with routine western medicine therapy on hypertensive renal damage may have protective effect, and its curative effect was superior to simple maleic acid enalapril and amlodipine and atorvastatin cutting atorvastatin calcium therapy. |
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Keywords: | Hypertension renal Kidney Injury Xuebijing injection Integrated Chinese traditional and western medicine therapy |
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