雄激素受体表达与新疆早发性乳腺癌临床病理特征及预后的关系

目的：研究雄激素受体（AR）表达与新疆早发性乳腺癌患者（年龄≤35岁）的临床病理特征及预后的关系。方法收集新疆医科大学附属肿瘤医院2010年1月至2012年12月经手术切除的浸润性乳腺癌且年龄≤35岁的标本145例，免疫组织化学方法检测其 AR 表达情况，回顾性分析其临床病理特征及预后与 AR 表达之间的关系。结果在新疆早发性乳腺癌中 AR 阳性表达率为69．0％（100／145），单因素分析结果显示 AR 表达与神经脉管侵犯（χ2＝5．309，P ＝0．021）及淋巴结转移（χ2＝6．073，P ＝0．014）有关，而与民族（χ2＝0．097，P ＝0．755）、年龄（χ2＝0．045，P ＝0．831）、哺育史（χ2＝0．066，P ＝0．797）、肿瘤家族史（P ＝0．556）、组织学分级（P ＝0．469）、肿瘤最大径（χ2＝1．006，P ＝0．605）和临床分期（χ2＝4．381，P ＝0．223）无关。中位随访时间47个月，AR 表达与新疆早发性乳腺癌的无瘤生存时间无关（χ2＝1．972，P ＝0．160）。结论 AR 阳性的早发性乳腺癌更易出现神经脉管侵犯和淋巴结转移，可能对临床淋巴结转移阳性的早发性乳腺癌患者的治疗有一定的指导作用。

Relationships between androgen receptor expression and clinicopathological features and prognosis of early-onset breast cancer in Xinjiang

Objective To study the relationships between androgen receptor (AR)expression and the clinicopathological features and prognosis of young patients (age≤35 years)with early-onset breast cancer in Xinjiang.Methods One hundred and forty-five young patients (age≤35 years)with invasive breast cancer who underwent surgery in Affiliated Cancer Hospital of of Xinjiang Medical University from January 201 0 to December 201 2 were collected.The expressions of AR in 1 45 patiens with early-onset breast cancer were detec-ted by immunohistochemical method.The relationships between AR expression and the clinicopathological fea-tures and prognosis of patients with early-onset breast cancer were retrospective analysed.Results The posi-tive rate of AR expression of patients with early-onset breast cancer in Xinjiang was 69.0% (1 00 /1 45).Single factor analysis showed that AR expression was related with neurovascular invasion (χ2 =5.309,P =0.021 ) and lymph node metastasis (χ2 =6.073,P =0.01 4),but it was not related with ethnicity (χ2 =0.097,P =0.755),age (χ2 =0.045,P =0.831 ),feeding history (χ2 =0.066,P =0.797),family history of cancer (P =0.556),histological grade (P =0.469),tumor size (χ2 =1 .006,P =0.605)and clinical stage (χ2 =4.381 ,P =0.223).The median follow-up time was 47 months.There was no significant difference between AR expression and disease-free survival of patients with early-onset breast cancer (χ2 =1 .972,P =0.1 60). Conclusion Early-onset breast cancer patients with AR positive are more likely to appear lymph node metasta-sis and neurovascular invasion than the patients with AR negative,which has certain guidance means for the treatment of early-onset breast cancer with lymph node metastasis positive.